The BBC show - which sees celebrities reveal their pet hates and request to banish them to Room 101 - is being brought back to TV after four years, according to comedy site Chortle.co.uk.
Comedian Skinner has appeared on the show as a guest, and confessed his hatred of Action Man toys and Shakespeare.
Nick Hancock fronted the show when it was launched in 1994 and Paul Merton took over as host in 1999.
Hat Trick Productions are yet to confirm when the show will return or how many episodes they are planning.
Little Britain's David Walliams and Matt Lucas are among guests rumoured to appear in the new series.
The last episode of Room 101 first aired in 2007 and the show has often been repeated.