Peanut Allergies – Have Scientists Finally Found A Cure?

First Posted: 11/10/11 12:53 Updated: 17/10/11 11:37

Scientists Find Potential Cure For Peanut Allergie

Scientists from the Northwestern University in Chicago have come one step closer to developing a potential cure for peanut allergies, by creating an immune system tolerant to peanuts.

The researchers found that they can switch off potentially deadly peanut allergy attacks by tricking the immune system into tolerating nut proteins, and not seeing them as a threat to the body.

The study involved attaching peanut proteins to white blood cells, meaning the immune system would recognise the protein and become tolerant to it. The medical tests were conducted on rats, but allergy experts hope that it can be replicated in humans, too.

"Their immune systems saw the peanut protein as perfectly normal because it was already presented on the white blood cells,” says assistant professor Paul Bryce.

Researchers from the study, published in the Journal of Immunology, also discovered that these findings opened up to opportunity to create a balanced immune system, by increasing the number of regulatory T cells - the immune cells important for recognising peanut proteins as normal in the body.

“T cells come in different ‘flavours’,” says professor Bryce . “This method turns off the dangerous Th2 T cell that causes the allergy and expands the good, calming regulatory T cells. We are supposed to be able to eat peanuts. We’ve restored this tolerance to the immune system.”

Scientists also found that they were able to attach more than one protein to the white blood cells, meaning other food allergies such as fish and eggs, can soon be combated too.

"We think we've found a say to safely and rapidly turn off the allergic response to food allergies,” adds professor Bryce.

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Scientists from the Northwestern University in Chicago have come one step closer to developing a potential cure for peanut allergies, by creating an immune system tolerant to peanuts. The researche...
Scientists from the Northwestern University in Chicago have come one step closer to developing a potential cure for peanut allergies, by creating an immune system tolerant to peanuts. The researche...
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adamben
yes i said yes i will yes
17:11 on 11/10/2011
i hear that that in europe, and when i was growing up when there were no gmo, allergies were much, much, much less to peanuts. so, maybe it would be easier to research what in the gmo peanuts is causing people to be allergic rather than changing our immune system. was this study paid for my monsato?
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HUFFPOST COMMUNITY MODERATOR
jbarelli
I don't belong to an organized political party.
20:58 on 11/10/2011
Unfortunately, it seems that non-gmo, standard peanuts trigger the allergic reaction as well.

Although it has always seemed odd that peanut allergy is such a Western European/North American phenomenon. African aid organizations use peanut based foods to help famine situations, and I haven't heard of any allergy problems.

Could it be that when we started sterilizing everything that small children touch we also changed how their immune systems naturally develop?
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adamben
yes i said yes i will yes
22:27 on 11/10/2011
well, i haven't heard of anyone testing either one of those possibilities; lots of work for some scientist out there.
21:33 on 11/10/2011
There are no GMO peanuts on the market.

Many epidemiologists link the modern surge of autoimmune disorders in the Western world to the hygiene hypothesis: the idea that vastly improved sanitation and immunization is weakening the developing immune systems of young children and promoting sensitivity to harmless substances.
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HUFFPOST SUPER USER
Giverny
Truthiness
22:11 on 11/10/2011
I don't agree with that hypothesis. I have always had allergies and introduction of non-native foods to a diet is more likely to result in a reaction. I used to eat anywhere as long as I avoided my allergy foods and the less clean the kitchen, the more likely I would respond with a salmonella bacteria response. Too many children died prior to this past century from simple forms of bacteria that are no longer the risk. We now have a global diet by trade and with the influx of canola for instance, I can rarely eat out because of the anaphylaxis. We also have imported pathogens that were unknown to this country previously. I know that the cleaner I kept my home and children, the less ills we had to deal with. Even being a bit strict in the virus season about who visited due to our immune issues. Foods we think of as clean are not and those that were once washed and packaged are not always a standard coming from countries less regulated. I watched a documentary where workers were picking tomatoes and packaging them in the field. I believe it is a global soup of bacteria we have not all been exposed to or have been able to generate through generations of resistance to being exposed. I am sure this is occurring in other countries as well with 'germs' we have been able to reduce to a common 3 day illness.