New KG5 Drug Brings Fresh Hope To Cancer Sufferers With Aggressive Tumours

New Cancer Drug That Kills Off Aggressive Tumours

The Huffington Post UK   First Posted: 14/11/11 13:06 GMT Updated: 14/11/11 13:06 GMT

Scientists have developed a new cancer drug that kills aggressive and deadly tumours by altering the structure of the cancer growth protein.

Researchers from the University of San Diego have created a drug that rivals the current drug called RAF, which merely blocks the activity of the tumour. The new drug, KG5, is able to change the shape of the protein and neutralise the tumour.

The KG5 drug has only so far been tested in laboratory cell lines, animals and tissue samples from patients.

However, the findings have scientists hoping that it could help treat a wide range of the fastest growing and most aggressive cancers, in the future. They also hope that this drug will stop the common problem of cancers developing a resistance to the treatment.

Talking about how they found KG5 more efficient over the current RAF drug, professor David Cheresh from the study said, "It's an unusual discovery, one that really challenges current dogma. In essence, we are attacking an important enzyme in a whole new way and thereby discovering new things this enzyme was intended for."

Different variants of KG5 have already been discovered and scientists are hoping these more potent versions will soon enter clinical trials.

The research was published in the Nature Medicine journal.

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Scientists have developed a new cancer drug that kills aggressive and deadly tumours by altering the structure of the cancer growth protein. Researchers from the University of San Diego have creat...
Scientists have developed a new cancer drug that kills aggressive and deadly tumours by altering the structure of the cancer growth protein. Researchers from the University of San Diego have creat...
 
 
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02:38 PM on 11/14/2011
This is such a poorly written article - the reporter really has so little idea of anything. The workers are at the University of California-San Diego, not the University of San Diego, which is a completely different institution - one is a major research university with a medical school, one is a Catholic liberal arts college. There is no one "cancer growth protein", there are many. RAF is not a drug, it is a target of a number of drugs, and a protein. The KG5 drug changes the structure of RAF. It is a disservice to have such poorly qualified reporters trying to write on technical subject.
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Dwayne Robbins
Trust me, I'm a Doctor.
03:16 PM on 11/14/2011
Well...it is Huff Post...surely you weren't expecting perfection or well researched and properly edited journalism.
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Craig Bovia
Vermont, 1791, women can vote, no slavery allowed
08:36 PM on 11/14/2011
Dwayne, do you always bite the hand that feeds you? Or in your case, gives you a forum for you displeasure.
An occasional thank you would suffice.
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Craig Bovia
Vermont, 1791, women can vote, no slavery allowed
08:34 PM on 11/14/2011
F/F for your imput. Thank you.
Regardless, it does sound hopeful.
02:21 PM on 11/14/2011
Few are the people who have not wondered why drugs cost what they do and, when the price tag has a pinch, sighed with exasperation. My solution: If only drug companies stopped wining and dining physicians, the price would go down. Also, if only CEOs weren’t so greedy, people without health insurance may enter into a "free medication program" and research program. In other words, patients will actually pay for their medication while participating in their (Pharma Company) Clinical Research Program. Its easy and convenient for both sides.
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02:04 PM on 11/14/2011
Good news for a Monday morning. Keep it up America pharmaceutical companys doing good.
Aren't you glad your here. Now think how it got that way. Independant or by Government?
Vote Freedom of Choice. Keep America unlike any other country. Stop Socailism now.
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Dwayne Robbins
Trust me, I'm a Doctor.
01:45 PM on 11/14/2011
Another pill that drug companies will charge an exorbitant amount of money p/dose. Average people won't be able to afford it and insurance companies won't pay for it.
09:23 AM on 11/16/2011
While I agree that prices for pharmaceuticals can be exorbitant and often drugs are prescribed when not strictly necessary, I feel the need to point out two facts that previous posters may not be aware of: firstly, UCSD is a university, NOT a drug company. They are doing vital basic science research. Although it is true that their end goal is to find compounds that may treat cancer, in doing so this sort of research peripherally generates a tremendous amount of knowledge about how the body and disease states work, providing the underpinnings for future care and treatment. If at some point the university can license the compound to a drug company for further development, the profits will help keep the doors of the university open and fund further research. Secondly, it costs a tremendous amount of money to bring a drug all the way from initial screening through safety and efficacy trials and eventually to market. fewer than one in ten drugs that start the prossess ever make it to market. The profits on one drug are what is required to push the next successful drug through the pipeline. I know that when you or a loved one is sick and unable to afford medication, it is easiest to blame the drug companies, but the situation is, in reality, a bit more complicated.
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Dwayne Robbins
Trust me, I'm a Doctor.
12:11 PM on 11/16/2011
I don't disagree with you Katie, however drug companies spend millions of dollars promoting their drugs. You can't go 30 minutes without a 2 minute commercial for a drug. Add that up. Go to the doctors office...there is everything from ink pens to wall plaques advertising their drug. Add that up. Also, my wife works in the medical field, drug companies routinely buy lunch for her office....about 150 employees...and they are not buying Big Macs, they are bringing in lunch from some of he nicest restaurants in town. Add this up. And consider the cost nationwide. Understandably, when these drugs are produced there is money spent on research, trials, etc. However, there is substantial amounts wasted on promotion. I mean come on, they have a captive audience, and people making decisions based on emotion. By bro-in-law died of cancer. In an effort to keep him alive, my sister spent over $100,000 (out of pocket, that doesn't include what insurance paid) on chemo. Really? Chemo drugs costs an average of $10,000 per week. I don't feel sorry for the drug companies.