Potent Alzheimer's Vaccine 'Could Prevent Disease From Developing'

Vaccine That Could Help Prevent Alzheimers

The Huffington Post UK   First Posted: 16/11/11 11:51 GMT Updated: 16/11/11 11:51 GMT

Scientists believe that a potent Alzheimer's vaccine jab could be the secret to preventing the disease developing from its early stages.

Researchers from Georgetown University Medical Center in Washington found that an antibody for Alzheimer's disease is more likely to trigger inflammation in the brain the later it is given and that it could potentially be prevented, as long as the vaccine is taken during the very early stages of the disease.

The study suggests that by giving vaccines to patients before tell-tale signs of Alzheimer's set in, it could halt the formation of the debilitating disease.

American scientists found that the PFA1 vaccine could help patients with lower levels of the toxic amyloid protein (which builds up over time in Alzheimer's sufferers), as it proved successful when the vaccine was tested on lab rats. Animals with large amounts of amyloid protein were more likely to suffer from brain inflammation.

Although the tests have only taken place on lab rats so far, researchers are hoping that their findings will one day eradicate Alzheimer's disease. Scientists just need to develop a general vaccine and discover an accurate way of detecting early signs of the disease.

"Excessive inflammation is counter-productive because it will limit the benefits of the vaccine treatment, and in a few cases, will cause new problems," says lead researcher, Dr. R. Scott Turner.

"We may find that in the future, we will have to tailor immunisation therapies based on amyloid burden in individual patients," Dr. Turner added.

Dementia affects 820,000 people in the UK and 25 million of the UK population have a close friend or family member with dementia.

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Scientists believe that a potent Alzheimer's vaccine jab could be the secret to preventing the disease developing from its early stages. Researchers from Georgetown University Medical Center in Wa...
Scientists believe that a potent Alzheimer's vaccine jab could be the secret to preventing the disease developing from its early stages. Researchers from Georgetown University Medical Center in Wa...
 
 
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10:29 PM on 11/18/2011
This article is misleading. When you read the study it refers to it becomes apparent that this vaccine's developers merely think that they are on the right track. Giving this vaccine to people produces brain inflammation, less if given earlier in the progression of Alzheimer's disease. They are assuming that their vaccine will lessen amyloid plaque deposition in the brain, and have no evidence of this. A recent study (Aug 2011) has shown that Alzheimer's is likely caused by spirochete infection, and that the amyloid plaque is a much later development. This article and its title are poorly written.Check out www.jneuroinflammation.com/content/8/1/90 for evidence of the very convincing theory that Alzheimer's is caused by spirochetes.
06:20 PM on 11/20/2011
Amyloid plaques are a later development as I've already posted. Spirochetes have been extensively studied and not renowned for causing plaques as far as I remember. Possibly not a good idea to suggest to people granny's Alzheimer's is the result of syphylis.
01:27 AM on 11/18/2011
Actually a potential possible problem is too many strands of and too much at an early age for some. This could be the cause (or early cause of aut park and alz) The intestinal tract needs to be formed for 1 or 2 yrs just by eating current foods. If not, the will leak into the bloodstream and goes to the brain.
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HUFFPOST SUPER USER
isis
Job 39:5 - Who has sent out the wild ass free?
01:15 PM on 11/17/2011
Is it sinking in how much good science we have with President Obama? This vaccine. An HIV vaccine. Fusion breakthroughs. Hydrogen storage breakthroughs.
04:52 PM on 11/17/2011
What in the world does Obama have to do with it???
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HUFFPOST SUPER USER
isis
Job 39:5 - Who has sent out the wild ass free?
11:22 PM on 11/17/2011
Science funding, esp in the area of energy.
karen1963yorks
My micro bio was empty. Good.
12:31 PM on 11/19/2011
While I dont credit Obama with the research it is true that the Bush administration held back stem cell research for no good moral or ethical reason. Some people prefer to pray for a cure. Thats ok for them but I dont see why they should stop the rest of us having something a little more effective. I also dont think people should be allowed to let their own children die in the name of their religion. Example blood transfusions.
07:05 PM on 11/17/2011
While I'm an Obama fan, I do have to point out that he doesn't have a whole lot to do with a lot of the research you just cited. The studies that were recently published about these *potential* vaccines have been going on for year, far longer than Obama has been in office.

While politics certainly affect and influence science (e.g. the increased NIH funding under Obama), such recent scientific breakthroughs can't be attributed to the president.
12:08 PM on 11/17/2011
My mother is now in the moderate stages of this disease and requires daily care and support from helpers additional to my father, who is himself frail. Absolute prevention would be a dream come true. I lament that this avenue, should it be found suitable to humans, shan't be available to my dear mum.
This comment has been removed.
05:16 PM on 11/16/2011
THIS IS THE MOST HORRIBLE DISEASE EVER.MY DAD HAS IT,AND IT IS JUST AWFULL TO WATCH SOMEONE YOU LOVE SUFFER WITH THIS. THEY HAVE NO QUALITY OF LIFE,EVENTUALLY THEY DONT REMEMBER WHO YOU ARE,IT IS SOUL DESTROYING HAVING TO WAIT FOR THEM TO ;CLOSE THEIR EYES; AND BE AT PEACE. I REALLY HOPE SOME BOFFIN WILL FIND A CURE,AND SOON ..
01:41 PM on 11/17/2011
Your caps lock is on.
05:14 PM on 11/16/2011
Here's hoping it is one of the most degrading conditions that destroy's not only the patients life but the families lives to so a drug that could prevent it would be brilliant
05:05 PM on 11/16/2011
Another reason for mandatory vaccinating the whole population, and making huge profits for the pharmaceutical companies!
karen1963yorks
My micro bio was empty. Good.
07:07 PM on 11/16/2011
PERHAPS YOU WOULD PREFER A RETURN TO MEDIEVAL CURES.
RUB A DOCK LEAF ON THAT PLAGUE BURN A WITCH AND RING THE CHURCH BELLS.
THOSE EVIL SCIENTISTS GOING ROUND GIVING PEOPLE INSULIN ANTIBIOTICS AND CAT SCANS
01:42 PM on 11/17/2011
Your caps lock is on.
10:39 PM on 11/18/2011
I am truly in awe of modern medicine in many aspects. Vaccines have become compulsory in most states (mine offers a philosophical exemption) due to the lobbying efforts of the pharmaceutical industry. I am not against vaccines. You can have them if you want. I have yet to find convincing evidence of their safety and efficacy. In fact, what I find is often the opposite. It is truly a myth that mass vaccination has saved the world from many diseases.
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cominginsecond
06:15 AM on 11/17/2011
Vaccines are not a huge profit center for drug companies. Far from it, in fact.
karen1963yorks
My micro bio was empty. Good.
12:39 PM on 11/19/2011
I have to say to the many people who whinge about drug compamies making profits. These companies produce things that not so many years ago in human history would have been considered magic of the highest order. So if you dont like it dont pay for it. Go and find one of those MRI scanners people build and operate for free. Another point is if you work for a week do you then refuse to accept payment?
karen1963yorks
My micro bio was empty. Good.
03:01 PM on 11/16/2011
This could be a fantastic breakthrough. Chalk up another one for science.
01:17 PM on 11/16/2011
Another publicity stunt by a bunch of scientists. Alzheimer's is a syndrome rather than disease, a collection of symptoms and signs which tend to occur together to form a characteristic pattern, but which not necessarily always due to the same pathological cause or causes.
karen1963yorks
My micro bio was empty. Good.
03:02 PM on 11/16/2011
SO YOUR CURE FOR IT IS?
05:09 PM on 11/16/2011
There isn't a cure once you have got it. Although I did see someone who had made amazing progress with coconut oil! It is a lifestyle disease! Avoid processed food, flu vaccines and as many pesticides and chemicals as you can.
05:53 PM on 11/16/2011
Indeed, Nicki already answered there isn't a cure. Remember the old adage 'Prevention is better than cure', the problem being there normally isn't any money in prevention. In fact these boys have got the right idea, persuade the FDA you've found a vaccine that prevents the disease. Would I buy it? Absolutely not, nor will the FDA for that matter!
06:29 AM on 11/17/2011
Alzheimer's DISEASE is a specific disease process- dementia can be described 'a collection of symptoms and signs which tend to occur together to form a characteri­stic pattern, but which not necessaril­y always due to the same pathologic­al cause (disease) or causes'.
Obviously, this vaccine comes too late for people who post nonsense, and will never be effective for ignorance.
08:03 AM on 11/17/2011
I'm grateful to see your comments, Jackrocks. It seems Mr. indlovubill has done precious little study of human cadavers nor has he observed a human brain with confirmed Alzheimer's Disease. To say the least, upon doing so, the word "syndrome" is not what comes to mind. Offering scientific commentary is not like offering sports commentary where you can just stand on the sidelines and imagine you have an informed opinion. Science actually requires knowledge.
08:42 AM on 11/17/2011
Alzheimer's is a form of dementia, cause or causes unknown so what is termed in medical publications Alzheimer's DISEASE (read my post properly) is more likely to be a syndrome. If you or CaroPinto would care to refer me to peer reviewed papers identifying a specific single cause of Alzheimer's I'll be pleased to hold my hand up and post an apology.