Avastin Drug Slows Ovarian Cancer Growth By Six Months, Study Finds

Drug That Slows Growth Of Ovarian Cancer

The Huffington Post UK   First Posted: 29/12/11 20:38 Updated: 29/12/11 22:05

Scientists have trialed a drug that can potentially slow down the progression of ovarian cancer down by up to six months.

Trial leader Dr Amit Oza, from Princess Margaret Hospital in Toronto, Canada, said, "This is the first new drug in ovarian cancer in 15 years to improve outcome and I believe it should be considered as a potential new standard of care," according to the Press Association.

The first trial on over 1,500 women found the drug acted as a better preventative than chemotherapy and delayed the cancer spreading by an average of two months – up to six months in those suffering from the aggressive form of ovarian cancer.

The results from the trial, published in The New England Journal of Medicine, followed the women as they were randomly given chemotherapy or a combination of standard chemo and Avastin following surgery to remove the cancer tumour.

After 28 months of follow-up with the patients, the researchers noted the difference in the delay of the disease between moderate and severe ovarian cancer cases.

A second study, involving 1,873 patients with previously untreated advanced ovarian cancer from 336 sites, mainly in the US. Patients were either given chemotherapy on its own or with the addition of Avastin, with some having an extra course of Avastin.

For women given two Avastin treatments, disease progression was delayed by around four months compared with those only receiving standard chemotherapy.

If this discovery makes you feel positive, check out other astonishing medical breakthrough of 2011.

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Scientists have trialed a drug that can potentially slow down the progression of ovarian cancer down by up to six months. Trial leader Dr Amit Oza, from Princess Margaret Hospital in Toronto, Canad...
Scientists have trialed a drug that can potentially slow down the progression of ovarian cancer down by up to six months. Trial leader Dr Amit Oza, from Princess Margaret Hospital in Toronto, Canad...
 
 
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SoCalDoc
Here's my opinion...like it or not!
02:07 on 30/12/2011
This is a not uncommon occurrence in medicine......several studies, all of which appear to be credible, which apparently contradict each other. This makes it quite difficult for doctors, let alone patients, to make treatment decisions. The articles from the Huffington Post do not provide sufficient detail to definitively explain this discrepancy; however, the study from the Princess Margaret Hospital appears to be looking at newly diagnosed patients while the studies from Fox Chase Cancer Center and from England seem to have studied patients with advanced disease and not necessarily newly diagnosed patients. Oftentimes a drug will be found to be effective only in a certain situation, as may be the case here. Clearly, the reasons for the discrepancies between the studies needs to be clarified and hopefully a biomarker will be identified which will help select the patients that would most likely benefit from such an expensive drug.
21:10 on 29/12/2011
Uhm.. wut? Literally on the same page, we have this article: http://www.huffingtonpost.ca/2011/12/28/ovarian-cancer-benefits-avastin-study_n_1173403.html

Which states explicitly that the side effects outweigh the benefits and they won't even bother trying to get the drug approved for use on ovarian cancer in the US. Is someone reading old science or something?
13:13 on 30/12/2011
The results of the two studies reported are quite similar. The difference in interpretation seems to be down to whether you focus on progression-free survival (time until the tumour gets worse) or overall survival (life expectancy). Both studies showed some improvement in progression-free survival (which is what this article focuses on).
Because of the way the US study was conducted, it is unlikely to find a difference in overall survival, although this does not mean that Avastin does not increase overall survival.
The study in Canada and UK (ICON7) has not yet collected enough data to say whether Avastin improves overall survival for all women. The results published this week are interim results. The final results, that will answer the question of whether Avastin improves overall survival for the women in the trial, will be available in 2013. But, encouragingly, there is enough data to show that Avastin seems to be particularly beneficial for women at highest risk of disease progression, increasing this sub-group's overall survival by almost 8 months.
18:07 on 30/12/2011
Why thank you! That greatly clarifies the situation. Maybe you should be a writer around here. ;)