The Grammy-winning rapper and actor says the February 12 broadcast is "gonna be a great night" and that his hosting duties are a dream come true.
He will be the first host in seven years for the show.
The Recording Academy has already named some performers - the Foo Fighters, Taylor Swift, Bruno Mars and Jason Aldean.
It will be LL Cool J's first time hosting the Grammys. He has hosted the live Grammy nominations concert since it began in 2008.
The Grammys will be broadcast on CBS from Los Angeles. The rap legend is a star on the network's NCIS: Los Angeles.
The last host of the Grammys was Queen Latifah.