Del Boy and Rodney are heading Stateside after ABC commissioned a pilot show, penned by Scrubs writers Steven Cragg and Brian Bradley.
The move comes 30 years after the show first aired on the BBC and became a huge hit, running up until 1996 when the hapless siblings finally became millionaires by auctioning off a watch that was worth a fortune.
Despite a series of reinvented British sitcoms flopping in the US, bosses are hoping to follow in the footsteps of Ricky Gervais, whose hit show The Office has translated well for American fans.
However, David Jason is convinced the show will be impossible to recreate for viewers abroad.
He said: "They can do brilliant comedy but I don't see that they can bring off Fools and Horses.
"I don't see that it will travel across the pond. The language will have to change so much and there will be so many parts of the storyline you have to change.
"It's so London and so British in its humour that you wonder. I have no idea what the American equivalent of 'plonker' is, for example. Or 'dipstick'."
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