The rocker will take on his first stage role playing The Artilleryman in the The War of The Worlds - The New Generation, based on Jeff Wayne's 1978 concept album.
Wilson joins the show with fellow new West End actress Kerry Ellis, and Wayne admits he's thrilled to work with both stars.
He says: "Over the years, I've been so fortunate to have had the participation of some truly great artists. For me, the real bonus is that I've always been a true fan of those who I've approached and when they've come on board, to me it's not been 'work', just great fun.
"Already, Ricky Wilson and Kerry Ellis fall into that category. Ricky because of his command on stage with the wonderful Kaiser Chiefs, and Kerry who I saw in the original production of Wicked in London's West End, whose voice and charismatic performance drew the audience to her like a magnet. I welcome them both to The War of the Worlds."
The show, which also features a 3D holographic 'appearance' from actor Liam Neeson, will tour arenas across Europe, including the UK, Ireland, Germany, Portugal, Poland and Finland. Wilson will begin his stint when the Kaiser Chiefs' current tour ends.