Single Antibody Found To Shrink Seven Different Cancers

The Huffington Post UK  |  By Posted: 27/03/2012 15:47 Updated: 27/03/2012 16:21

Cancer Cure Drugs

Scientists have developed a drug they claim could cure cancer, after discovering a single antibody that has been found to shrink seven common types of the disease.

A treatment that targets a protein responsible for blocking the immune system from protecting the body against cancer tumours, has been successfully trialled on laboratory mice.

The drug could slow the growth of cancer tumours and, if taken early enough, even offer a cure, the researchers claim.

The results, published in the Proceedings of the National Academy of Science, reveal the drug successfully blocked the harmful CD47 protein and shrunk human breast, ovary, colon, bladder, brain, liver and prostate tumours which had been implanted into the mice.

The ‘miracle drug’ works by targeting and blocking the CD47 protein - a biomarker that stops the immune system doing its job by telling it to kill healthy blood cells instead of protecting them. The cancer tumour uses this protein to protect it from being destroyed.

Although this technique was discovered a decade ago by biologist Irving Weissman from Stanford University School of Medicine and is already used to treat leukemia and lymphoma, this is the first time research has suggested that it could be just as effective with other types of cancer tumours.

Talking to Science, Weissman, who participated in the study, said: “What we’ve shown is that CD47 isn’t just important on leukemia and lymphomas. It’s on every single human primary tumour that we tested.

We showed that even after the tumour has taken hold, the antibody can either cure the tumour or slow its growth and prevent metastasis.”

However, although the researchers have been given multi-million dollar funding to extend their research from mice to humans, they added that it is unlikely the drugs will available anytime soon.

"We have enough data already, that I can say I'm confident that this will move to phase I human trials,” added Weissman.

Responding to the findings, Dr Kat Arney from Cancer Research UK, told HuffPost Lifestyle: "While the headlines may promise a miracle cure, this ‘wonder drug’ is still at its earliest stages and has only been shown to work in the lab and in mice.

“But it’s certainly an interesting and potentially exciting approach, and we look forward to seeing the results of further work to find out whether anti-CD47 can actually treat cancer in patients safely and effectively.”

Dr Richard Francis from Breakthrough Breast Cancer, added: “It’s exciting that further research is planned into this promising new avenue for cancer treatment. We look forward to finding out whether this drug will be safe and effective for breast cancer patients. However, research so far has only been carried out in mice and it will be several years before we know if humans can benefit.

"We’d encourage anyone with questions about their breast cancer treatment to speak to their doctor.”


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Scientists have developed a drug they claim could cure cancer, after discovering a single antibody that has been found to shrink seven common types of the disease. A treatment that targets a protei...
Scientists have developed a drug they claim could cure cancer, after discovering a single antibody that has been found to shrink seven common types of the disease. A treatment that targets a protei...
 
 
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05:34 PM on 03/28/2012
If this was discovered a decade ago why the blazes hasn't it been looked into more thoroughly before now? How slow the wheels of progress do turn. It seems that looking for ancient planets is more important than looking for treatments for something a bit closer to home.
HUFFPOST SUPER USER
onionboy
Blessed are the Cheese Makers
05:15 PM on 03/28/2012
Not to be downer, but this isn't exactly the first time I've heard "our antibody works on all primary tumors". I will hold out hope.
12:20 PM on 03/28/2012
I have had quite a few friends now over the past 10 years who have all died through cancer
It seems they are always saying how they can cure, but I have rarely if ever seen anyone cured of it yet. It all seems such a life sentence once you have it.
I know the cancer charities say that is not true, but in reality it is.
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HUFFPOST SUPER USER
nikki717
War...what is it good for?
06:57 AM on 03/28/2012
Interesting development. I will certainly keep an eye on this.
06:56 AM on 03/28/2012
Having thought about this for the last few hours since my last posting, I see a few have similar view as mine. The comments about 'yet to be approved for people' given the current approval for human use, is quite frankly, a bloody insult to our intelligence, and at least a further explanation should be demanded and forthcoming. (Or is the Big Pharma arrogance simply finally gone "off the chart"?).

Any 'follow through' messrs journalists ????
05:33 AM on 03/28/2012
Every single life threatening disease with a multi billion dollar charity attached to it, for research, is on a slow boat. Money trumps saving lives - just like the drug companies who hold the world hostage with drug pricing. That is huge power!

If this protein has worked on cancer patients with leukemia and lymphoma why would it not be considered safe or at least worth a try for others fighting for their lives with no other alternative. I would rather take the chance that it might work than wait for all the mice to be cured.
01:08 AM on 03/28/2012
Great news. Problem is it goes with all the other 'great news' cancer breakthroughs we've heard about over the last few decades. The crunch of the story is, "they added that it is unlikely the drugs will available anytime soon." Nothing ever seems to come of any of them. It sounds more like, "We need more grants. Look at what we might have found." The only constant here is that the cancer charities are the richest in the world.
12:23 AM on 03/28/2012
If it already is used for leukemia, why not also use it for the others?

Ten years since, and only has been tested on mice? How many potential 'terminal' patients would be willing participants? 100% ? I have no doubt.
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10:10 PM on 03/27/2012
Wonder if chemotharpy will be reduced. This treat, in the video, I found involves no chemo.
http://vimeo.com/24821365
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pepekitch
08:58 PM on 03/27/2012
Great news,hope it works on humans, fingers crossed.
08:19 PM on 03/27/2012
Great news.
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tissa
Chicago Liberal /Sales/Marketing Director
07:26 PM on 03/27/2012
Good news, good work.
06:21 PM on 03/27/2012
If it's already being used to treat leukemia and lymphoma as the article states, why not for the others? What am I missing here?
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JBS
Part time misanthrope & full time curmudgeon
11:08 PM on 03/27/2012
They are only recently discovering that it works for other cancers. Probably its effect on other cancers was first noticed while treating leukemia patients & that's what led to the animal studies which are required before they can test whether it works on humans. They'll have to prove it works on humans before the drug will be approved for general use.
11:52 PM on 03/27/2012
I hope it proves to work very well.
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srpw0903
It's not what u look, it's what u see that matters
06:10 PM on 03/27/2012
They are always finding drugs to cure cancer in mice, dogs, etc. When they begin testing in humans the situation immediately changes and the drugs are not compatible. Well, after so many failures when will "they" admit that testing on other animals is USELESS????? Duh...
They obviously need to devise a method of testing on HUMAN TISSUE, perhaps from stem cells?? Ignorance is bliss, they repeatedly make the same mistakes and REFUSE to learn from their errors. The mice population now can live cancer free.......
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Reality always bites
Sometimes just a bit peckish
08:28 PM on 03/27/2012
A real glass half empty comment. Would you care to complete a bit of research and enlighten us all as to the complete list of failures (ie -where the situation immediately changes and developed drugs are not compatible)
Then have a look at the number of major developments in medicine and drug therapies that have been sucessfully introduced following theses sort of trials.
08:26 AM on 03/28/2012
I agree with you and how much will this £2 a dose cure cost us each when they actually find it to work.......... Only the very rich can afford it even though they get most of there funding by the working class people. Free for anyone wanting to seek asylum mind! i sat on a train the other day and heard a ruck sack shout out to another neart ruck sack - does my bomb look big in this! This country is doomed get out while you can.
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Norman Mitchison
05:43 PM on 03/27/2012
Billions of pounds on research and they are still treading water.
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tissa
Chicago Liberal /Sales/Marketing Director
07:27 PM on 03/27/2012
Sounds like you think this is easy to do....by all means please try yourself....
08:20 AM on 03/28/2012
Dear Tissa,please accept my offer to continue the testing of my own possible cure of all top cancer growths.
I have tested some of my products on earth worms which since have proven a better catch for my fellow friends that are keen fisherman which leaves me just one very small problem.
for just 3 million pounds of your money we could go fishing more every day and use the bait that we feed our home spaghetti bolognaise to so we can continue on our speedy research and hopefully by doing this then one day we just might find another whom would be happy to continue the contribution of fundings on when you leave this world. Yours truely Mr J R Hartley