Police are investigating the circumstances surrounding the death on Tuesday, but it is believed that Calvuna Reese's unnamed brother accidentally pulled the trigger of a loaded gun.
The news has sent shock waves around the community in Memphis, Tennessee, U.S., with one neighbour, Randy Lark, telling the local TV station: "Oh it tears me up. It really, really hurts. I'm so shocked and hurt by what happened to this child."
Randy added: "Everyone should learn from that lesson, not to leave a loaded gun around a kid."
The shooting comes just two days after a similar incident in Kentucky when 15-month-old Bella San Martin was shot dead by her three-year-old brother in their family's Kentucky home on Sunday.
Police involved said it was a tragic accident and that the parents were home at the time.
For more information on the sad story in Kentucky, watch the video news report below: