Plans have been submitted to use the Olympic Stadium as part of a London Formula One Grand Prix route after the Games.
West Ham United and Leyton Orient, along with the UCFB College of Football Business are the other bidders involved, according to The Daily Telegraph.
In June, Bernie Ecclestone revealed he was willing to spend £35m to bring a grand prix to England's capital city.
Following Ecclestone's plea, a video of the proposed route was uploaded, taking in landmarks such as Nelson's Column, Trafalgar Square, Piccadilly Circus and Buckingham Palace during the race.
Ecclestone confirmed he had been approached, revealing a firm "came up with a scheme whereby Formula One would race around the stadium, inside it, outside it".
The four bids will be assessed prior to negotiations, the London Legacy Development Corporation confirmed, adding the F1 offer came via Intelligent Transport Services.
Orient's proposal includes ground-sharing with West Ham, however Hammers owners David Gold and David Sullivan have vowed not to consider such an arrangement.
West Ham initially had a deal in place to lease the stadium for £486m in 2011, but legal wrangling ultimately scuppered the possibility.
Tottenham Hotspur also explored the possibility of moving to Stratford as they explored options to upgrade on White Hart Lane, although the club's supporters vehemently opposed the move.
UCFB, meanwhile is currently based at Championship club Burnley's Turf Moor ground.