Madonna has dedicated a striptease to the Pakistani schoolgirl who was shot in the head by Taliban gunmen.
Appearing on stage in Los Angeles, the 54-year-old singer addressed the audience saying it was time for a “serious chat”.
Revealing the news of the attack on 14-year-old Malala Yousafzai had “made her cry” she asked the crowd: “Do you understand the sickness and absurdity of this?”
Madonna then proceeded to perform a striptease, turning around to reveal the world “Malala” written on her back, The Hollywood Reporter said.
Malala was shot with two classmates as they made their way home from school in Swat, in the north west of Pakistan.
She was attacked by the Taliban for promoting girls' education and criticising the militant group.
Malala was only 11 when she started documenting how difficult it was to get an education: "I dreamt of a country where education would prevail," she wrote.
Her anonymous blog, first published by BBC Urdu, documented Taliban atrocities committed in Pakistan’s Swat Valley and saw the schoolgirl receive international praise.
Her life was saved by neurosurgeons in a Pakistani military hospital and she has since remained in intensive care.
But doctors decided she needed "prolonged care" to help her recover from the physical and psychological effects of the attack.
Foreign Secretary William Hague said the UK was standing "shoulder to shoulder" with Pakistan after the attack.
Madonna's dedication sparked strong feelings among Twitter users who were divided between branding her "crass and hypocritical" and thanking her for her for bringing the Malala's plight to a world stage.
Madonna is no stranger to mixing politics and sex on stage. In September the singer delivered a political rant on freedom in which she referred to President Barack Obama a "black Muslim".
The Like A Virgin singer mused on how "amazing and incredible" it is that "we [America] have an African-American in the White House ... we have a black Muslim in the White House".
Earlier in her MDNA tour the mother-of-four flashed her nipple at fans during a show in Istanbul.
And in Tel Aviv, Israel, she upset French National Front leader Marine Le Pen when she projected an image of a Nazi swastika on the politician's forehead onto large screens around the stage.