Acknowledging the fact it only took Hitler six months to destroy democracy and become Fuehrer with the aid of an apathetic public, she called on Germans to always fight for their principles and not allow complacency.
She said: "Human rights do not assert themselves on their own; freedom does not emerge on its own; and democracy does not succeed on its own.
"No, a dynamic society ... needs people who have regard and respect for one another, who take responsibility for themselves and others, where people take courageous and open decisions and who are prepared to accept criticism and opposition," reports AP.
The sombre anniversary is being marked in Germany with a number of cultural events and a special session of parliament
The museum is holding a 'Berlin 1933-The Road To Dictatorship' exhibition examining the key moments leading to Hitler's appointment.
The building is situated in the grounds of the SS headquarters and documents letters from many of the victim's of the state-sponsored terror.
An open-air exhibition at the Brandenburg Gate will remember the sinister torchlit march of thousands of SS stormtroopers that marked Hitler's appointment.
Hitler's legacy still casts a long shadow over world events. Last week saw both the Sunday Times and Lib Dem MP David Ward forced to apologise for invoking Nazi imagery.
Celebrating this anniversary is a reminder that today's events are not as detached from history as we would like to believe.
Another global economic depression has led to a surge in neo-Nazi groups particularly in Greece.