Argentina could only manage a 1-1 draw in Bolivia as players suffered playing at a high altitude, with Lionel Messi reportedly being sick on the pitch.

Nearly 4,000 metres above sea level, the La Paz atmosphere apparently caused the Barcelona forward to throw up while Real Madrid winger Angel di María required the aid of an oxygen mask. Javier Mascherano tweeted a picture after the match which also showed Paris Saint-Germain attacker Ezequiel Lavezzi inhaling through an oxygen mask.

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Di María requires an oxygen mask as the altitude takes its toll

Bolivia went ahead through Marcelo Martins in the 25th minute when he nodded past Sergio Romero before Ever Banega equalised for Argentina.

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An upbeat Lavezzi poses for a team photo

Despite the draw, the Argentines top the Conmebol qualifying group in South America, four points ahead of Ecuador, who have a game in hand.

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Messi and Mascherano pause for a breather

Bolivia's hopes of reaching Brazil have all but extinguished as they lie second from last in the table.

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  • Angel Di Maria

    Argentina's Angel Di Maria lies on the pitch after missing a chance to score against Bolivia during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Lionel Messi

    Argentina's Lionel Messi reacts during a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Juan Karita)

  • Argentina players greet each other at the end of the game against Bolivia during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. The game ended tied 1-1. (AP Photo/Martin Mejia)

  • Javier Mascherano, Pablo Guinazo, Franco Di Santo, Leonardo Ponzio

    Argentina players, from left, Javier Mascherano, Pablo Guinazo, Franco Di Santo and Leonardo Ponzio react at the end of the game against Bolivia during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. The game ended tied 1-1. (AP Photo/Martin Mejia)

  • Marcelo Moreno Martins

    Bolivia's Marcelo Moreno Martins celebrates after scoring a goal as his during a World Cup 2014 qualifying soccer match against Argentina in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Juan Karita)

  • Lionel Messi

    Argentina's Lionel Messi controls the ball during a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Juan Karita)

  • Lionel Messi

    Argentina's Lionel Messi catches his breath during a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. The match ended tied 1-1. (AP Photo/Juan Karita)

  • Angel Di Maria

    Argentina's Angel Di Maria inhales oxygen during a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Juan Karita)

  • Lionel Messi

    Argentina's Lionel Messi sits on the pitch during a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Juan Karita)

  • Jose Basanta, Edward Zenteno, Walter Veizaga, Sergio Galarza

    Argentina's Jose Basanta, right, shoots over Bolivia's Edward Zenteno (21) and Walter Veizaga as Bolivia's goalkeeper Sergio Galarza, left, looks on during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. The match ended 1-1. (AP Photo/Martin Mejia)

  • Lionel Messi, Walter Veizaga

    Argentina's Lionel Messi, right, fights for the ball with Bolivia's Walter Veizaga during a World Cup 2014 qualifying soccer match in La Paz, Bolivia, March 26, 2013. (AP Photo/Juan Karita)

  • Lionel Messi

    Argentina's Lionel Messi sits on the pitch at the end of a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. The match ended 1-1. (AP Photo/Martin Mejia)

  • Lionel Messi, Marvin Bejarano

    Argentina's Lionel Messi, right, fights for the ball with Bolivia's Marvin Bejarano during a World Cup 2014 qualifying soccer match in La Paz, Bolivia, March 26, 2013. (AP Photo/Juan Karita)

  • Argentina fans pose for a picture before the start of a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, March 26, 2013. (AP Photo/Juan Karita)

  • Lionel Messi, Walter Veizaga

    Argentina's Lionel Messi, left, fights for the ball with Bolivia's Walter Veizaga during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Angel Di Maria

    Argentina's Angel Di Maria inhales oxygen during a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Juan Karita)

  • Lionel Messi, Ronald Raldes, Walter Veizaga

    Argentina's Lionel Messi, center, fights for the ball with Bolivia's Ronald Raldes, left, and Walter Veizaga during a World Cup 2014 qualifying soccer match in La Paz, Bolivia, March 26, 2013. (AP Photo/Juan Karita)

  • Alejandro Sabella

    Argentina coach Alejandro Sabella gives instructions to his players from the sidelines during a World Cup 2014 qualifying soccer game against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. The match ended 1-1. (AP Photo/Juan Karita)

  • Evo Morales, Lionel Messi

    In this photo released by Bolivia's Presidential Press Office Argentina's soccer star Lionel Messi tries a Bolivian poncho given to him by Bolivia's President Evo Morales, left, after of a World Cup 2014 qualifying soccer match with Bolivia in La Paz, Bolivia, March 26, 2013. (AP Photo/Bolivia's Presidential Press Office)

  • Angel Di Maria

    Argentina's Angel Di Maria inhales oxygen during a World Cup 2014 qualifying soccer match against Bolivia in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Juan Karita)

  • Angel Di Maria

    Argentina's Angel Di Maria lies on the pitch after missing a chance to score against Bolivia during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Ronald Raldes, Angel Di Maria

    Argentina's Angel Di Maria, left, fights for the ball with Bolivia's Ronald Raldes during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Sergio Galarza, Rodrigo Palacio

    Bolivia's goalkeeper Sergio Galarza, center, clears a shot by Argentina's Rodrigo Palacio (16) during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Angel Di Maria, Edward Zenteno, Alejandro Chumacero

    Argentina's Angel Di Maria, center, fights for the ball with Bolivia's Edward Zenteno, right, and Alejandro Chumacero during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Sergio Galarza

    Bolivia goalkeeper Sergio Galarza fails to stop the ball during the goal of Argentina's Ever Banega during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Bolivia's Marcelo Martins, second from the left, celebrates with his teammates after scoring against Argentina during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Ever Banega, Clemente Rodriguez, Lionel Messi

    Argentina's Ever Banega, right, celebrates with his teammates Clemente Rodriguez, center, and Lionel Messi, after Ever scored a goal against Bolivia during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Ever Banega, Sebastian Dominguez, and Lionel Messi

    Argentina players Ever Banega, Sebastian Dominguez, and Lionel Messi stand on the pitch after the first goal of the game was made by Bolivia during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Lionel Messi, Luis Gutierrez

    Argentina's Lionel Messi, left, fights for the ball with Bolivia's Luis Gutierrez during a World Cup 2014 qualifying soccer match in La Paz, Bolivia, March 26, 2013. (AP Photo/Juan Karita)

  • Lionel Messi, Walter Veizaga, Alejandro Chumacero

    Argentina's Lionel Messi, right, fights for the ball with Bolivia's Walter Veizaga, left, and Bolivia's Alejandro Chumacero, center, during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Lionel Messi, Walter Veizaga

    Argentina's Lionel Messi, right, fights for the ball with Bolivia's Walter Veizaga during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • Angel Di Maria, Walter Veizaga

    Argentina's Angel Di Maria, right, fights for the ball with Bolivia's Walter Veizaga during a 2014 World Cup qualifying soccer game in La Paz, Bolivia, Tuesday, March 26, 2013. (AP Photo/Martin Mejia)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Bolivia's Marcelo Moreno Martins (C) celebrates with teammates Jair Torrico (L) and Carlos Saucedo after scoring against Argentina during the Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Sebastian Dominguez (L) vies with Bolivia's Jose Luis Chavez during their Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JORGE BERNAL (Photo credit should read JORGE BERNAL/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Angel Di Maria (L) and Lionel Messi gesture during the Brazil 2014 FIFA World Cup South American qualifier football match against Bolivia, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Hugo Campagnaro (L) and Lionel Messi gesture during the Brazil 2014 FIFA World Cup South American qualifier football match against Bolivia, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Angel Di Maria takes oxygen as he is assisted during the Brazil 2014 FIFA World Cup South American qualifier football match against Bolivia, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Ever Banega celebrates after scoring against Bolivia during the Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentine forward Lionel Messi (C) is marked by Bolivian midfielder Ronald Garcia during their FIFA World Cup Brazil 2014 South American qualifying football match in La Paz, Bolivia on March 26, 2013. AFP PHOTO / AIZAR RALDES (Photo credit should read AIZAR RALDES/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Angel Di Maria takes oxygen as he is assisted after a fall during the Brazil 2014 FIFA World Cup South American qualifier football match against Bolivia, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Lionel Messi (C) controls the ball next to Bolivia's Bolivia's Walter Veizaga (R) during their Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. The match ended 1-1. AFP PHOTO / AIZAR RALDES (Photo credit should read AIZAR RALDES/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Lionel Messi (C) controls the ball next to Bolivia's Walter Veizaga (R) during their Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. The match ended 1-1. AFP PHOTO / AIZAR RALDES (Photo credit should read AIZAR RALDES/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Bolivia's goalkeeper Sergio Galarza jumps to catch the ball during their Brazil 2014 FIFA World Cup South American qualifier football match against Argentina, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / AIZAR RALDES (Photo credit should read AIZAR RALDES/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Marcos Rojo (L) and Javier Mascherano (R) vie for the ball with Bolivia's Carlos Saucedo during their Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / AIZAR RALDES (Photo credit should read AIZAR RALDES/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Supporters of Bolivia display a banner remembering their 6-1 win against Argentina in the qualifiers for the South Africa 2010 World Cup, as they wait for the start of the Brazil 2014 FIFA World Cup South American qualifier football match between their team and Argentina, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Supporters of Argentina cheer before the start of the Brazil 2014 FIFA World Cup South American qualifier football match between Bolivia and Argentina, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Angel Di Maria (L) and Bolivia's Walter Veizaga vie during their Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Lionel Messi (L) is marked by Bolivia's Marcelo Moreno Martins during their Brazil 2014 FIFA World Cup South American qualifier football match, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Argentina's Javier Mascherano gestures during the Brazil 2014 FIFA World Cup South American qualifier football match against Bolivia, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG

    Supporters of Bolivia cheer before the start of the Brazil 2014 FIFA World Cup South American qualifier football match between Bolivia and Argentina, at the Hernando Siles stadium in La Paz, on March 26, 2013. AFP PHOTO / JUAN MABROMATA (Photo credit should read JUAN MABROMATA/AFP/Getty Images)

  • FBL-WC2014-QUALIFIERS-BOL-ARG-SUPPORTERS

    Bolivian supporters are seen before the start of a Brazil 2014 FIFA World Cup South American qualifier football match against Argentina at Hernando Siles stadium in La Paz, Bolivia, on March 26, 2013. AFP PHOTO / Juan Mabromata (Photo credit should read JUAN MABROMATA/AFP/Getty Images)