According to the Daily Star, the star - nicknamed Holly Willough-booby by Keith Lemon on the ITV2 panel show - was said to be leaving the show at the end of the next series to spend more time with her family.
Holly Willoughby with Keith Lemon and Fearne Cotton on 'Celebrity Juice'
However, Holly shot down the rumours on Twitter, writing on Sunday night: "Ooosh? Whose leaving where???? The names willou-booby...holly Willough-booby! X (sic)."
Holly - who also presents 'This Morning' and 'Surprise Surprise' - previously quit her role as co-host of 'The Voice UK' to spend more time with her two children - Harry, four, and Belle, two.
"Finding the right balance between my work and family life is my priority and this has contributed to my decision," she said.