Elisabetta also married in Italy, where George is set to tie the knot with Amal Alammudin too.
However, Elisabtta, 36, chose to marry Brian, 46, in Alghero, Sardinia, and looked beautiful in a voluminous layered lace dress as she arrived for the ceremony at the Sassari Cathedral.
She had her brown hair curled and pinned to the side, and she waved to the crowds who had gathered to see her.
The model carried a bouquet of white flowers and wore her veil over her face as she entered the church.
And it was all smiles (and veil pinned back) when the newlyweds emerged and ceremonial rice was thrown.
The happy couple started dating at the end of 2013 after Elisabetta split from Jackass star Steve-O.
She has never been married but, according to the Daily Mail, has been engaged twice before to soccer star Christian Vieri and film director Gabriele Muccino.
She famously dated George Clooney for 18 months before the pair split in June 2011.
George is set to wed lawyer Amal, 36, this month in Venice. The actor recently revealed the ceremony would not take place at his Lake Como villa.
At the Celebrity Fight Night In Italy Gala on Sunday (7 September), George gave a speech - and dished up some details.
He said: "I met my lovely bride-to-be here in Italy, whom I will be marrying, in a couple of weeks, in Venice, of all places."
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