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Scientists Discover New Antibody Which Could Help Fight Cancer

12/12/2014 11:31 GMT | Updated 12/12/2014 11:59 GMT
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Scientists have found a new type of antibody which could help treat cancer by boosting a person's immune system.

Antibody IgG2B is more effective at stimulating cancer immunity than previously known forms, according to researchers at the University of Southampton.

Unlike other forms of antibody, IgG2B can work independently without needing help from other immune cells, making it more active and able to work in all tissues of the body, meaning it could be a stronger immune stimulator than previous drugs.

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Dr Ann White, who led the study funded by Cancer Research UK and published in the journal Cancer Cell, said: "We know that the immune system provides a natural protection against cancer, which can only grow by finding a way around our defences.

"Antibody treatments are now able to correct this problem for many types of cancer, but we still need them to work better.

"It is early days, but this important discovery could enable us to treat more cancers effectively.

"Our next task is to bring these novel IgG2B antibodies into trials for cancer patients and we are engineering ways to make them effective in the clinic."

She explained that the precise shape of an antibody makes a big difference to how it can stimulate the body's immune system to fight cancer, paving the way for much more effective treatments.

This new antibody has been created in a "locked B" structure and the team are to begin research to establish why this shape is so effective.

The latest types of treatment for cancer are designed to switch on the immune system, allowing the patient's own immune cells to attack and kill cancerous cells, when normally the immune cells would lie dormant.

Professor Nic Jones, Cancer Research UK's chief scientist, said: "This research has zeroed in on how we can make immunotherapy treatments more effective against cancer.

"Energising the immune cells in our body and getting them to treat cancer cells as a threat gives us a better shot at beating cancer.

"Immunotherapy is part of the future of cancer treatment and it's important that we use our best immunotherapy weapons to fight the disease."

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