Michelle Obama will visit a girls school in east London as part of her two-day visit to the United Kingdom.
The First Lady's 2009 visit to the Elizabeth Garrett Anderson school in Islington, during the Obamas' first trip to Britain after the president's election, electrified the students - who screamed and ran to hug her on stage.
This time Mrs Obama will speak to the students of Mulberry School for Girls in Tower Hamlets. She will take questions from the girls alongside former Australian prime minister Julia Gillard.
While in London, Mrs Obama will also meet David Cameron, his wife Samantha and Prince Harry.
Accompanying Mrs Obama on her Europe trip, which also includes visits to Madrid and Venice, will be her mother, Marian Robinson, and daughters, Malia and Sasha.
In her 2009 speech at Elizabeth Garrett Anderson, the Mrs Obama said she had been "surrounded by extraordinary women in my life who taught me about quiet strength and dignity" and encouraged the students to "control your own destiny".
"Whether you come from a council estate or a country estate, your success will be determined by your own confidence and fortitude. It won't be easy, that's for sure, but you have everything you need. Everything you need you already have right here.
In a speech designed to inspire the young girls to not hold back on ambition, she added: "We are counting on you, we are counting on every single one of you to be the best that you can be."
Despite there being over a year left of the Obama presidency, attention in the US has already turned to the 2016 race for the White House.
On Saturday, Hillary Clinton kicked off her campaign to become the first female president. The front runner for the Democratic nomination won applause in a New York speech by telling the crowd: "I may not be the youngest candidate in this race, but I will be the youngest woman president in the history of the United States."
Jeb Bush, the brother of George W. Bush, is due to formally announce he will join an already crowded Republican field this week.