SNP leader Nicola Sturgeon spoke out on Monday about the furore raging over allegations the prime minister once "put a private part of his anatomy in a dead pig's mouth" as part of a university initiation.
The claims are contained within a book written by billionaire Tory donor Lord Ashcroft, due to be published next month but serialised in advance by the Daily Mail.
While the '#PigGate' phenomenon has gripped social media and news outlets, with fresh news that Cameron's Oxford associate, now Chancellor, George Osborne smiled when asked about the incident, hundreds of politicians and public figures have responded with merciless glee.
But Scottish First Minister Nicola Sturgeon led the trolling charge, telling journalists that Cameron had certainly been the cause of much entertainment.
Asked about the pig incident claim, she told Channel 4: "I don't think I'm in any position to comment on the revelations about David Cameron.
"I think though, if I can perhaps make a few bets, he's entertained the whole country on a dreary Monday morning - so there's got to be something in that."
Sturgeon went on to address one of the more serious claims contained in Lord Ashcroft's text, which says that Cameron knew of the Tory peer and party bankroller's non-dom status earlier than previously thought.
On Monday it was claimed that as early as 2009, Lord Ashcroft discussed with the Prime Minister how they could delay revealing his "non-dom" tax status - which allowed the ennobled donor to avoid tax on overseas earnings - until after the following year's general election.
It would completely contradict the Conservatives assertion at the time when the controversial status became known in 2010 that Cameron had been told only a month before.
Lord Ashcroft – who had given a commitment to become resident in the UK for tax purposes when he was made a life peer – subsequently gave up his non-dom status to retain his place on the Conservative benches in the Lords.
Commenting on the tax status criticism, a Labour shadow minister piled in on Sturgeon's calls, saying: “Amidst the furore around Lord Ashcroft’s new book there lies a serious question mark over the consistency of the Prime Minister’s statements about the peer’s tax status".
Jonathan Ashworth, MP for Leicester South, said the allegations had raised "a serious question mark over the consistency of the Prime Minister’s statements about the peer’s tax status".
“Lord Ashcroft stated today that he made the Prime Minister fully aware of his non-domiciled status in 2009. However in March 2010, when his status was made public, David Cameron said the full details were ‘only’ known by Lord Ashcroft and the Inland Revenue.
The MP added: "Furthermore, [the Prime Minister's] spokesperson confirmed that David Cameron was only made aware of the Peer’s status the previous month."
A Downing Street spokesperson told The Huffington Post UK: "We’re not going to be commenting on any of it."
Sturgeon's intervention in the debate comes after Lib Dem leader Tim Farron posted a jovial message hours after the pig allegations surfaced.
I've never been more pleased to be a vegetarian.— Tim Farron (@timfarron) September 20, 2015
The book, titled 'Call Me Dave', is due to be published next month.
It tracks Cameron's journey as a student at Eton and Oxford to Downing Street and sheds light on his career in PR, where he reportedly made many enemies.