The semi-sheer lipstick, defined as a "bright cherry red", comes in a gold tube with Loren's signature painted on the side.
The lipstick was launched only a few weeks after the Italian actress' 81st birthday.
Domenico Dolce and Stefano Gabbana said in a press release: "Sophia Loren N°1 is our way of saying, 'Thank you, Sophia'.
"Thank you for her beauty, thank you for being a world favourite, thank you for being an icon of the big screen and of Italian beauty.
"She has been a constant source of inspiration for us and today we celebrate her with the gift of her very own lipstick."
The designers released photos and a 40-second, behind-the-scenes video of Loren modelling the new lipstick in their ad campaign.
Looking stunning a black lace dress, she serves up a reminder that age is just a number. What a babe.
Sophia Loren N° 1, created by Dolce&Gabbana in loving tribute to the Italian beauty icon.September 17, 2015