The 41-year-old, who plays Steve McDonald in the soap, said Emma Gleave experienced a slow four-week labour that ended with her waters having to be broken.
Gleave called it the "most painful experience" she'd ever had because in the end, she had no time to be given any drugs.
"I went into slow labour at 36 weeks so we kept saying, 'It won’t be long' then it kind of went on forever," Gleave told OK! Magazine.
Gleave, who said she experienced contractions every hour from week 36, said those last four weeks of pregnancy were extremely hard.
She added: "They told me it would take at least 24 hours for anything to happen after breaking my waters, but within a few seconds of them breaking my waters I was in labour."
The couple's son, Henry Teddy was born on 11 December weighing 8lb 1oz.
Gregson said: "Giving birth is amazing. There is no way blokes could do it. Not a chance!"
Gregson announced on Twitter on 16 December 2015 that Gleave had given birth to the couple's third child together.
The actor said he was "thrilled" to finally meet his son.
He tweeted: "After talking to a belly for nine months, I can now talk to a beautiful little face and know it’s not Mr Hanky. Myself and @emmagleave are thrilled."
Gregson and Gleave married in 2010 and also have two older sons - Alfie, seven and Harry, five.
Since the birth of Henry, Gregson has been updating his fans with comical statuses on Twitter.
Dear Santa thank you for the gift of this baby I've now been awake for over a week do you take returns. Lots of love aaaaggghhhhhhhhhhhhhh😳— simon gregson (@simongregson123) December 25, 2015
I would like to shake hands with whoever invented the wet wipe but only if I had a wet wipe handy— simon gregson (@simongregson123) January 6, 2016
The hunt for brown October has finally ended and a tiny little man can smile once more 💩😄💩😄— simon gregson (@simongregson123) January 6, 2016
Read the full interview in this week's OK! magazine - out now.