In that time, Peake has opened up space exploration to a whole new generation, as well as inspired old cynics about the the beauty of space travel.
During his time away from Earth, he has won our hearts with backwards somersaults, beautiful pictures of the sunrise from space and even ran a flipping marathon (in space). He even revealed what happens to a fart in space.
Oh, and who could forget when he accidentally called the wrong number?
A former helicopter test pilot Major Peake, 44, became the first Briton to join the ISS as a European Space Agency (ESA) astronaut on December 15 last year.
This Saturday, he will travel back to Earth with American colleague Colonel Tim Kopra and Russian cosmonaut Yuri Malenchenko.
The trip, made in a Soyuz TMA descent capsule, departing at 3.15am BST before undocking from the space station at 6.30am BST, comes with its hazards.
Striking atmosphere at more than 17,000mph, a safe landing will depend heavily on friction, which will envelop the module in temperatures of up to 1,650°C (3,000°F).
They will then deploy parachutes and retro-rockets to slow their descent further until they halt in the Kazakhstan Steppe at around 10.15am BST.
Major Peake, who has worked 14-hour days and taken part in over 250 scientific experiments, had his return delayed due to the postponed launch of the replacement crew.
Speaking to reporters about his return, he said: "It goes without saying that I'm ost looking forward to seeing my family but also enjoying planet Earth.
"I love the outdoors and having lived on the space station for six months I am looking forward to some fresh air and getting outdoors.
"I most miss the rain. I've not had a shower for six months so the feeling of nice cold drizzle on my face seems quite blissful.
"I'm sure most people in the UK will find that remarkable."