His knuckle tattoo, of Heard's nickname 'Slim', has now been changed to say 'Scum' - with the 'l' and 'i' being redrawn as a "c" and "u", respectively.
This wasn't the only inking of Depp's bearing Heard's nickname, he also has the phrase "Come with me... Slim" on his right elbow, and a portrait of her on his arm - which he has since covered up according to photos on TMZ.
Depp's tattoo on 23 May 2016.
The tattoo on 1 July 2016.
Heard's nickname is reported to be a reference to actress Lauren Bacall, known for playing Slim against Humphrey Bogart's Steve in the 1944 film 'To Have and Have Not'.
In a 2011 interview, promoting their film 'The Rum Diary', Depp told USA Today: "When I first saw Amber, it was like seeing an old-time movie star. It was like I was seeing Lauren Bacall."
This isn't the first time Depp has altered a tattoo after a break up - in 1994 he changed a tattoo dedicated to ex-girlfriend Winona Ryder which read 'Winona forever' to say 'Wino forever'.
Also on HuffPost
Suggested For You
SUBSCRIBE AND FOLLOW
Get top stories and blog posts emailed to me each day. Newsletters may offer personalized content or advertisements.Learn more