The supermodel is featured in both the editorial images (above) and a racy new video advert (pictured below).
The 42-year-old fashion icon first modelled for the Calvin Klein aged 16, starring in an Obsession perfume ad, shot by her then boyfriend Mario Sorrenti, and an iconic photoshoot for Calvin Klein Jeans, posing topless next to Mark Wahlberg.
"Spanning three decades, Kate’s modeling career is unparalleled," Calvin Klein said in a statement about the decision to get the supermodel back on board.
"She is both a trendsetter and a cultural icon. In every image of her, no matter what she wears or how she transforms, she is and will always be Kate."