British student Meredith Kercher was killed in Italy in November 2007, but the chain of events and who was responsible is still being disputed. Rudy Guede is serving a reduced sentence of 16 years, but Amanda Knox and Raffaele Sollecito are appealing their murder convictions.
Here are the key dates - from Kercher's murder to the Knox and Sollecito's appeal:
2007
September - Amanda Knox arrived in Perugia, where she moves into a house with Meredith Kercher, a 20-year-old exchange student from Surrey.
1 November - Bar owner, Patrick Lumumba, cancels Knox’s shift at his bar, Le Chic. Between 9pm and 11pm Kercher is murdered. Knox says that she met boyfriend Raffaele Sollecito that night.
2 November - Sollecito and Knox say Kercher is missing but police break down Kercher’s bedroom door. They find her half-naked with a stab wound in her throat.
4 November - A post-mortem examination shows that there was sexual activity before Kercher died.
6 November - Knox, Sollecito and Lumumba are arrested
19 November - Rudy Hermann Guede, a drug dealer, is also named as a suspect. Lumumba is released.
22 November - Guede admits being in the house on the night of the murder.
30 November - Knox and Sollecito are denied bail.
14 December - Meredith Kercher is buried back in Britain.
2008
11 January - It is revealed that police found traces of a bloody footprint in Knox's bedroom.
1 April - Knox, Sollecito and Guede lose their appeals to be released.
9 September - Guede opts for a fast-track trial.
28 October - Guede is sentenced to 30 years for murder. A vaginal swab taken from Kercher had matched his DNA. He admitted to police that he had engaged in sexual relations with Kercher, but claimed that someone killed her while he was in the bathroom.
2009
16 January - Sollecito’s and Knox’s murder trial begins.
6 March - Lumumba sues Knox for libel for £462,000
12 June - Knox claims that she was at Sollecito’s house as her alibi. She claims that police interrogators pressured her and hit her in the head during interrogations - a claim that officials denied.
4 December - Knox and Sollecito are convicted. Knox is sentenced to 26 years and Sollecito to 25 years after they are found guilty of murdering Kercher.
2010
24 November - Knox and Sollecito's appeal against their convictions starts.
2011
29 June - Forensic specialists tell the court that DNA evidence linking Knox to the alleged murder weapon is unsound, giving a boost to her appeal. They agree Knox's DNA was present on the knife handle, but tests for Kercher's DNA were unreliable.
25 July - Two forensic experts tell the court that the suspected murder weapon may have been contaminated with other DNA traces.
5 September - Prosecutors defend the DNA tests. Kercher's sister urges people to "please remember our beautiful Meredith."
26 September - Patrick Lumumba's lawyer calls Knox a "she-devil". Knox said that she wrongly implicated Lumumba because of police pressure.
29 September - Wrapping up the defence case, Knox's lawyer urges the jury to look beyond the media image of Knox.