Empty government offices will be offered to budding entrepreneurs hoping to launch their own businesses, David Cameron will say on Monday.
The prime minister plans to open vacant and under-used workplaces to small firms and new enterprises in a bid to kick-start the economy.
He will unveil the initiative during a visit to Yorkshire where he is due to address a group of entrepreneurs.
Cameron is expected to say: "The British government has a huge stock of buildings at our disposal.
"The first priority for the ones we aren't using is to sell them off, but in the meantime, many are going to be sitting idle.
"So let's match the capacity we've got with the need that's out there. Let's provide office space where we can to those who can use it."
The government hopes to offer more than 300 premises at low rates for one year so new companies can establish themselves and small firms can benefit from cheap deals.
With cuts to the public payroll, many government buildings lie empty or have space available as they await buyers.
As well as helping entrepreneurs, the initiative will give a much-needed boost to Treasury finances.
Cameron is expected to say: "I said 2012 has got to be the year we go for it, the year we light new fires of ambition in our economy, the year we get behind Britain's grafters, doers, hard-workers and entrepreneurs.
"This isn't something we'd quite like to do - it's something we've got to do because enterprise is critical to this country's future.
"Enterprise is what we do in Britain. This is the year that, more than ever, we've got to go for it."
The prime minister will also launch a campaign aimed at encouraging people to believe "there is a business in everyone".
The Business in You drive will see companies hold workshops and give advice on tackling some of the issues faced by would-be bosses, with the scheme highlighted in radio, newspaper and billboard adverts throughout the year.