A study has shown that a diet high in fat and calories can hasten the development of pancreatic cancer in humans.
In a presentation to the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, researchers said their results showed a clear link between diet and pancreatic activity.
"Our results showed that in mice, a diet high in fat and calories led to obesity and metabolic disturbances such as insulin resistance that are seen in obese humans," said Guido Eibl from the David Geffen School of Medicine at the University of California, according to a statement.
"It also greatly enhanced pancreatic inflammation and pancreatic cancer development."
Human epidemiological studies have linked high fat intake and obesity to an increased risk of pancreatic cancer, but the mechanism driving this association has not been understood.
To understand the link, Eibl and his colleagues first tested the hypothesis that diet is linked to cancer. They fed a corn oil-based diet that had a high content of fat and calories to mice with a genetic mutation that caused them to develop pancreatic precancer. The same gene, KRAS, is mutated in the majority of human pancreatic cancers.
The results showed that 90% of the mice fed the special diet became obese, and all of these mice developed insulin resistance and inflammation in the pancreas. Both of these conditions can stimulate the growth of precancerous cells and cancer. These mice also developed significantly more advanced precancerous lesions than did mice fed a normal diet.
"This suggests that the high-fat, high-calorie diet accelerated pancreatic cancer development," said Eibl.
"A KRAS mutation in the pancreas might not be sufficient to cause an individual to develop pancreatic cancer. It likely needs something in addition a secondary hit. Our study showed that a high-fat, high-calorie diet could provide an environmental secondary hit and trigger cancer development."
The researchers are now defining the role that inflammation produced by obesity plays in development of the cancer, and if agents such as antidiabetic drugs or fish oil can halt this disease process.