Pedro's second-half strike ensured Spain moved to the top of Group I after claiming a 1-0 victory at World Cup qualification rivals France, whose misery was compounded by Paul Pogba's red card.
The Tuesday night clash at the Stade de France offered the chance for both sides to stamp their authority on the group and it was world and European champions Spain who took advantage just before the hour.
France 0-1 Spain
Barcelona forward Pedro slotted home from close range following Nacho Monreal's cross from the left, as Hugo Lloris failed to punch the ball clear.
France's hopes of a share of the spoils took a blow when Pogba collected two quick bookings to see red in the 78th minute in just his second appearance for Les Bleus.
Victor Valdés was still called upon to deny Patrice Evra an equaliser with a stunning save as Spain held on to leapfrog France in Group I.