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A chartered Air Ads plane will fly overhead brandishing the message "Wrong one - Moyes out", after disgruntled supporters chipped in to protest against the club's manager.
The much-maligned "Chosen One" banner - which stewards were instructed to guard amid attempts to rip it down midweek - will remain on the Stretford End.
United were humbled 3-0 by neighbours City on Tuesday - their second consecutive home Premier League loss after Liverpool triumphed by the same scoreline.
The first signs of revolt were witnessed in the usually mundane south stand, where Sir Alex Ferguson was vocally abused by supporters over Moyes's appointment.
Ferguson personally chose Moyes to succeed him last year and the former Everton boss signed a six-year contract in May.
However, in his nine months at United he has broken several unwanted records, most recently when he oversaw the club's 10th League defeat of the season - an unprecedented number of losses in the Premier League era.
United were ejected from both domestic cups in January and are likely to finish outside of the European places for next season. Perhaps most humiliatingly for Moyes, Everton are well poised to finish above United.