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The US star has had a tough time in the house, and her decision to leave early was announced on Tuesday afternoon.
'CBB' bosses issued a statement on the matter, which read: "After being unwell for a few days, Angie Bowie has decided to leave the 'Celebrity Big Brother' House.
"Her exit will be addressed in tonight’s live show on Channel 5 at 9pm.”
Angie has previously threatened to quit the show on a number of occasions, after initially opting to stay after being privately informed of David Bowie's death.
In Monday's show, viewers saw Angie storm into the diary room and declare her intentions to leave, telling Big Brother: "You did it, you cracked me. It was all going to be peachy before you decided to have another one of your parties where you inebriate those people so I can't get any sleep.
“Get me my shit! I am not staying here another minute. Get me out of here now!”