Ben Stiller, Owen Wilson and Will Ferrell will strut their stuff on the red carpet as they arrive for a "fashionable screening" of Zoolander No. 2 in London's Leicester Square.
They will be joined by new co-stars Penelope Cruz and Kristen Wiig, who take centre stage in the sequel to 2001's Zoolander.
The film sees male models Stiller (Derek Zoolander) and Wilson (Hansel) attempt to reclaim their place in the world of high fashion.
Fifteen years on from the first film, Stiller is back as "really, really, really ridiculously good looking" Derek, famed for his "looks" including Le Tigre, Blue Steel and Magnum. He has now retired from the fashion industry.
Wilson returns to the role of fellow model and idiot Hansel, while Ferrell plays their fashion world enemy Mugatu - who starts the film in prison, serving a sentence for the attempted assassination of the prime minister of Malaysia.
But he is soon out and up to his villainous tricks, declaring: "Prison changed me. I am bad to the core now."
Cruz plays motorcycle-riding Valentina, an Interpol special agent (global fashion division), while Wiig puts on an almost-unintelligible accent and layers of make-up to play fashion mogul Alexanya Atoz.
In the sequel, a spate of celebrity killings has led to the death of Justin Bieber after a night-time chase scene through the streets of Rome.
All the victims mysteriously snapped photos of Derek's "looks" in their dying moments, with Bieber declaring "peace out world".
Desperate to get to the bottom of this, Valentina enlists the help of Derek and Hansel.
Others confirmed for the red carpet on Thursday include Stiller's wife Christine Taylor, who played journalist and Derek's love interest Matilda Jeffries in the first film, and screenwriter Justin Theroux.
:: Zoolander No. 2 is released in UK cinemas on February 12.