The actress, who currently plays Ronnie Mitchell in the BBC One soap, starred in the 90s ITV comedy series alongside Denise Van Outen, and has revealed her desire to revisit the show.
Speaking to the Daily Star, she said: “I was watching re-runs the other day and everyone’s saying ‘it’s the comeback season, you should bring it back!’
Samantha - who was then known by her previous surname, Janus - played 20-something Ruth on the short-lived sitcom, which aired on ITV from 1998 to 1999.
It was recently revealed that her ‘EastEnders’ character will be killed off along with her on-screen sister Roxy (played by Rita Simons) in dramatic scenes to air over the coming months.
However, the decision to bump off the Mitchell sisters was slammed by former Walford matriarch Barbara Windsor.
Speaking to The Sun, Dame Babs claimed it was Sean O’Connor - who took over as the show’s executive producer in June - who decided Samantha and Rita should bow out, rather than the actresses themselves.
“It wasn’t the girls’ choice. It’s the new producer’s decision,” she told the paper.
While the actresses themselves have remained silent on their departures, Samantha did tweet a cryptic message shortly after Barbara’s comments were published.
“Feeling loved and supported by my Auntie P,” she wrote. “Love her forever.”
It’s believed the the sisters’ exits will be at the centre of the soap’s Christmas action, and bosses have filmed multiple endings in order to keep vital storyline details under wraps.