Paul Scholes scored on his 700th Manchester United appearance and Alexander Buttner and Nick Powell netted on their Red Devils debuts in a 4-0 Premier League win over Wigan at Old Trafford.
Elsewhere, Arsenal beat Southampton 6-1 at the Emirates Stadium.
They had three points effectively sewn up at the interval, as own goals from Jos Hooiveld and Nathaniel Clyne and strikes by Lukas Podolski and Gervinho handed the Gunners a commanding lead before Danny Fox pulled one back.