"I actually feel that women in my position, when we have all at our disposal to help us, shouldn't complain," said mum-of-six Angelina.
"Consider all the people who really struggle and don't have the financial means, don't have the support, and many people are single raising children. That's hard."
Angelina's comments came after Gwyneth Paltrow - who recently split from husband Chris Martin - told E! news that it was much harder for her to juggle work and family life than someone who works nine-to-five:
"I think it's different when you have an office job, because it's routine and, you know, you can do all the stuff in the morning and then you come home in the evening," said the 41-year-old mum of Apple, 9, and Moses, 7.
"When you're shooting a movie, they're like, 'We need you to go to Wisconsin for two weeks,' and then you work 14 hours a day and that part of it is very difficult. I think to have a regular job and be a mom is not as, of course there are challenges, but it's not like being on set."
While promoting her new movie Maleficent, Angelina, 38, was asked whether she ever feels 'mum guilt.'
Rather than following in Gwyneth's lead and embarking on a self-pitying rant, Angelina responded with refreshing perspective:
"I'm not a single mom with two jobs trying to get by every day," she told New York Daily News. "I have much more support than most people, most women in this world. And I have the financial means to have a home and health care and food."
Angelina and Brad Pitt's six kids - Maddox, 12, Pax, 10, Zahara, nine, Shiloh, seven, and five-year-old twins Knox and Vivienne - are all home-schooled and travel everywhere with their globetrotting parents.
They even accompanied Angelina while she was promoting Maleficient,
"My kids, they're here upstairs," she revealed during the interview, pointing toward the ceiling of the hotel conference room.
But rather than moan about the difficulties of working with six children in tow, Angelina admitted that being a successful actress has its advantages, as she is currently in the enviable position of being able to set her own schedule while directing the WW II film Unbroken.
"I'm in a rare position where I don't have to do job after job. I can take time when my family needs it," she said. "I can say I can only get into the (editing) room after the kids are in school, and I have to be back for dinner, and they're coming for lunch."