The Mail published a report on Monday which stated Alamuddin's mother Baria wanted her daughter to marry "within their strict Lebanese religious sect."
On Wednesday, Clooney responded to the story by explaining how the newspaper had written a "completely fabricated story." His article, published on USA Today, has prompted the Mail to issue a statement of apology.
The original story has since been removed from the Mail Online.
Writing exclusively for USA Today, Clooney said, "I'm, of course, used to the Daily Mail making up stories - they do it several times a week - and I don't care."
"But this lie involves larger issues. The irresponsibility, in this day and age, to exploit religious differences where none exist, is at the very least negligent and more appropriately dangerous."
Clooney closed the piece by stating, "And when they put my family and my friends in harm's way, they cross far beyond just a laughable tabloid and into the arena of inciting violence.