The 54-year-old TV presenter said she's 'blessed' to be mum to Rosie, 20, but added she would have loved to have had 'a football team' of kids and had considered IVF, but had been put off by friends' experiences of the procedure.
Lorraine, who is celebrating 30 years as the face of breakfast TV, told The Mirror: "I would've loved to have had more kids, if that was possible.
"But to be honest with you, I didn't want it enough to go down that IVF road because I've got friends who have done it and it's hard.
"It might have been different if we hadn't had Rosie."
She added simply: "In an ideal world I would've loved a football team of kids."
It isn't the first time that Lorraine, who had a miscarriage in 2001, has opened up about her desire to have more children.
Speaking on Piers Morgan's Life Stories in 2013, she explained: "I'm really blessed to have my daughter, I have a beautiful girl.
"But I think my regret is not being able to have more kids, I would have really loved more kids.
"It just wasn't meant to be, and we didn't go down the road of IVF or anything like that, because we thought: 'If it's meant to happen if it happens, and we've been blessed with one.'"
But Lorraine isn't the type to dwell on what might have been.
She told the Mirror: "My job is a privilege, it genuinely is, and I will never take it for granted.
"If I could go back in time and tell my younger self something I'd say, 'It's going to be okay, don't stress so much. You're going to meet the man of your dreams, you're going to have a lovely child and you're going to be incredibly lucky'.
"There's so many people that would love to do this job. I'm not naïve enough to think it's going to last forever – nothing ever does – but my God it's been great fun."
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