Dr Fredric Brandt, the man who is credited with popularising the use of Botox, has been found dead at his home in Miami.
Brandt, 65, was a celebrity dermatologist popular with stars like Madonna, among others.
He was found hanged at his home after suffering with depression, according to reports.
The NY Mag reports that Dr Brandt was credited with creating the 'Y Lift', in which he injected filler under the cheekbones, and the 'Botox Neck Lift' in which Botox was injected into the neck as well as the face.
Brandt worked in leukaemia research before becoming a pioneer in cosmetic dermatology and launching his own line of products.
Allure magazine reports that his Dr Brandt's Lineless Lines No More is the number one bestselling dermatology product in the world.
He was also host of Sirius XM's 'Ask Dr. Brandt' for four years, where he was joined by stars like Kelly Ripa and Gwyneth Paltrow.
Brandt championed a healthy-lifestyle approach to beauty, enjoying yoga and a sugar-free diet. He tested products on himself, and once described his work to Interview, saying, "What I try to do is to make your face look like it did when you were younger. I always tell people it's not just about filling in the lines, but re-creating the shape of your face as it was in your early- or mid-twenties. I think it's all about restoring the contours. You can fill in a line and it makes you look a little better, but it doesn't make you look younger."
Some reports have suggested that a dermatologist character that looked uncannily like Brandt, played by Martin Short, made a couple of appearances in Tina Fey's new Netflix comedy, The Unbreakable Kimmy Schmidt.
According to Page Six, his publicist, Jacquie Tractenberg, said the show had hurt his feelings, but it could not be blamed for his death.
"The show definitely deeply hurt him, he was being made fun of because of the way he looks. It is mean, and it was bullying," she said.
"But the show was not the reason for his depression, and it was not the reason he would take his own life."
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