Gut Bacteria In Autistic Children Different From Non-Autistic Children

Gut Bacteria Different In Autistic Children

The Huffington Post UK   First Posted: 10/01/12 15:44 GMT Updated: 11/01/12 09:47 GMT

Scientists have found that the bacteria in the gut of autistic children is different from that of non-autistic children.

Researchers from the Mailman School of Public Health at Columbia University found that microorganisms residing in the gut of autistic children are different from other children but they are yet to determine whether these gut differences are a cause or an effect of autism, reports the American Society For Microbiology (ASMUSA).

The results, published in the mBio journal, found that a bacteria belonging to the Sutterella group in the gut was found in 12 of 23 tissue samples from autistic children. The same bacteria were not present in the samples of non-autistic children.

According to Jorge Benach, Chairman of the Department of Microbiology at Stony Brook University: “The Sutterella bacteria has been associated with gastrointestinal diseases below the diaphragm, and whether it's a pathogen or not is still not clear. It is not a very well-known bacterium."

Scientists are now hoping to find out why this organism is only present in autistic children.

“The relationship between different microorganisms and the host and the outcomes for disease and development is an exciting issue," says Christine A. Biron, Professor of Medical Science at Brown University.

"This paper is important because it starts to advance the question of how the resident microbes interact with a disorder that is poorly understood," adds professor Biron.

The study used tissue samples from the guts of the children. Scientists believe the results could provide a positive step towards finding a direct link between digestive problems and behavioural traits in autistic children.

“Most work that has been done linking the gut microbiome with autism has been done with stool samples," explains Benach. “But the microorganisms shed in stool don't necessarily represent the microbes that line the intestinal wall. "What may show up in a stool sample may be different from what is directly attached to the tissue.”

Georgina Gomez-de-la-Cuesta, Action Research Leader for The National Autistic Society added to this, telling The Huffington Post:

"People with autism can often experience gut problems, but there is little evidence to suggest a causal relationship between the two conditions. While this research identifies differences in gut bacteria between children with autism and children without the condition, more studies looking at children with a range of symptoms are needed to confirm any connection and understand the biological processes that underlie this.

"Managing gut problems can help improve behaviour for some people with autism by alleviating physical discomfort and stress. However, this should be viewed as a complementary method and is not a treatment for autism in itself."

The full report can be found on the mBio journal website.

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Scientists have found that the bacteria in the gut of autistic children is different from that of non-autistic children. Researchers from the Mailman School of Public Health at Columbia University...
Scientists have found that the bacteria in the gut of autistic children is different from that of non-autistic children. Researchers from the Mailman School of Public Health at Columbia University...
 
 
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03:50 PM on 02/07/2012
Other studies have previously connected to the fact that bad bacteria that is mostly left after the use of antibiotics kills off most of the 'good ' bacteria in the gut, which bad bacteria then grows in numbers in the gut, once the other bacteria has been mostly destroyed,....produces neural toxins, which explains the nature of the illness,and also explains the exponential increase in Austism since mid 20th century, it is much more than a casual relationship.
03:41 PM on 02/07/2012
Other studies , have identitified certian bacteria , more in autistic children ,in the gut, that produce neural toxins, which would make sense ,given the nature of autism...its the bacteria that is resistant to most antibiotics ; which when antibiotics kills off the good bacteria, and allows the toxic bacteria to increase,...which also would explain the exponential growth of the numbers of autism, since mid 20th century...the advent of antibiotics .
photo
SecularAdvocate
Media Watcher
09:08 PM on 08/27/2012
There's a difference between how much autism there is in the world and how much we notice it.

Try not to confuse the two.
HUFFPOST SUPER USER
nogggin
02:41 PM on 01/11/2012
Sorta sounds like what Wakefield was on about.
01:25 AM on 01/16/2012
Not even close. I've read Wakefield's studies. Hid idea was that mercury directly ingested, such as in tuna, isn't an issue, but minute level of mercury through shots will somehow be absorbed throughthe body into the digestive tract where it causes harm. Of course, he forget to tell people he was well paid by an attorney with a court case going or that he had things he developed he wanted to promote. The magazie that promoted him was his own. He was on the Board of the school in Texas that promoted him.
01:49 PM on 01/11/2012
Half of 23 tissue samples? Kind of weak, but worth more investigation.
09:49 AM on 01/11/2012
This feels like another Polio-Ice Cream correlation.
02:34 AM on 01/11/2012
If there is a relationship between the bacteria and autism it would be very interesting indeed but a mere 12 out of 23 is a very small sample and I'm unconvinced. There are doubtless many other factors to be taken into consideration before any conclusions can be drawn.
11:54 PM on 01/10/2012
Autism: The Eusocial Hominid Hypothesis
http://www.scribd.com/doc/74944514/

"ASDs are hypothesized as one of many adaptive human cognitive variations that have been maintained in human populations via genetic and epigenetic mechanisms. Introgression from 'archaic' hominids (adapted for less demanding social environments) is hypothesized to explain the initial discrete variation because inclusive fitness does not adequately model the evolution of distinct, copy-number sensitive phenotypes within a freely reproducing population."

That might explain the different microbiomes.
01:46 AM on 01/11/2012
Oh yeah, clear as a bell mate! Do you actually understand what any of that that means because I don't think you do? It's actually deeply insulting to the autistic who actually possess a significant but largely understood capacity for significant intellectual development. Perhaps you would, in your own words, give us your perception of autism?
02:03 AM on 01/11/2012
I take it you didn't actually take a look at the paper? This is from the first page:

“Eight autistic people have been associated with my group […] They are there because of their intellectual and personal qualities. I believe that they contribute to science because of their autism, not in spite of it.
The hallmark of an enlightened society is its inclusion of non-dominant behaviours and phenotypes, such as homosexuality, ethnic differences and disabilities. Governments have spent time and money to accommodate people with visual and hearing impairments, helping them to navigate public places and find employment, for instance — we should take the same steps for autistics.” --Laurent Mottron

The angle is hardly critical.

Also, I don't really know what this is about:

"It's actually deeply insulting to the autistic who actually possess a significan­t but largely understood capacity for significan­t intellectu­al developmen­t"

Did I say anything to the contrary?
09:29 PM on 01/23/2012
What does introgression from archaic hominids have to do with autism. Whatever introgression from archiac hominids, that is left in modern humans, is spread out through the general population. Not just in one percent of the population.

Neanderthal cognitive abilities were adapted to their environment tens of thousands of years ago. Since then all human beings have adapted to a different environment. Cognition in modern humans is likely significantly different than Neanderthals, all human beings, autistic and non-autistic.

This can't be a serious piece of research. It appears to be 57 pages of randomly cut and pasted research from others.

The research is not even credited to an author with any credentials in the paper. Are you the author?
09:59 PM on 01/23/2012
Does this clear things up for you?

When a queen lays eggs, he explained, each egg can develop into a different caste depending on the environment it is in - the temperature it develops at and the nutrition it receives. But the key to "switching" into a specific cast is controlled to a large extent by one chemical inside the eggs, which is called juvenile hormone.

"The fact that you can induce it in all these different species [that don't naturally have that caste], means that one common ancestor of all these species had [supersoldiers]."

"This ancestral potential is locked in place for 35 million years and... if you can find it, you can unleash [it]."
http://www.bbc.co.uk/nature/16424096

Different evolutionary patterns likewise emerge from comparative genetic analyses, which—among other aspects—have shown evidence for positive selection of genes related to cognitive development, that occurred after the split of H. sapiens and Neanderthals.[...] Although different regions of the prefrontal cortex (frontal lobes) have been associated with higher integrative and social functions, (for example, decision making), regions of the temporal lobes are traditionally related to visual memory, language and to **theory of mind.** All of them are compatible with higher olfactory functions.
http://www.nature.com/ncomms/journal/v2/n12/full/ncomms1593.html

Mutations in CADPS2 have been implicated in autism (67), as have mutations in AUTS2 (68).
https://www.sciencemag.org/content/328/5979/710.full
07:28 PM on 01/10/2012
As a parent of a 20 year old individual on the autism spectrum, it has been my experience that many individuals on the spectrum experience complex medical issues which are often "written off" by medical practitioners as Munchhausen by Proxy, and not taken seriously when parents raise health concerns. It is refreshing to see that unique health issues for individuals with autism are getting research attention, as well as attention in the media. Kudos to HuffPost Social News for covering this story and making it available on-line to a wide audience. Kathleen A. Whelan, M.F.A., LLC, Maple Shade NJ, USA