Breakthrough Gene Discovery 'Could Boost Fertility' Claim Scientists

PA/The Huffington Post UK  |  Posted: 1/05/2012 10:25 Updated: 1/05/2012 10:25

Fertility Gene

Scientists studying mice have identified a gene which could boost human fertility.

Experts say the discovery, announced in a journal today, could help people struggling to conceive naturally.

A Durham University team working with scientists from Osaka University in Japan were studying fertility in mice when they discovered that the gene, which makes a protein called PDILT, enables sperm to bind to an egg, a process essential to fertilisation.

They found that when the gene was switched off in male mice, less than 3% of females' eggs were fertilised compared to more than 80% in mice when the gene was left switched on.

It is the first time that a gene of this type has been linked to fertility.

Adam Benham, of Durham University's school of biological and biomedical sciences, said: "The protein is an essential part of the navigation system of sperm.

"It helps sperm swim through the oviduct to the egg and without it sperm get stuck.

"Our results show that navigating the oviduct is an important part of the fertilisation process.

"Like any navigation system, you have to programme where it is that you want to go and this protein plays an essential role in getting sperm to the right destination, in good shape, and in good time."

The researchers also found that the cumulus cells, a cluster of cells surrounding and protecting an egg, play an important role in fertility - their presence enables sperm to bind properly to an egg.

Although the research and findings are at an early stage, the researchers now hope to look at how the gene affects sperm-to-egg binding in humans.

The findings are published in the journal PNAS, Proceedings of the National Academy of Sciences.

Loading Slideshow...
  • Frozen Embryos 'More Successful Than Fresh' For IVF Preganancies

    Frozen embryos are more likely to produce successful, complication-free IVF pregnancies than those that are fresh, research suggests. Using stored embryos cuts the risk of bleeding in pregnancy, premature birth, and giving birth to an underweight baby by almost a third, a study has found. The risk of a baby dying at around the time of birth is also reduced by about a fifth. <a href="http://www.huffingtonpost.co.uk/2012/09/04/health-frozen-embryos-boost-ivf_n_1853377.html?utm_hp_ref=uk-lifestyle" target="_hplink">Read the full story here.</a>

  • Frozen Embryo IVF Babies 'Healthier And Heavier'

    IVF babies born from frozen embryos are heavier and healthier than those born from fresh embryos, new fertility research has discovered. <a href="http://www.huffingtonpost.co.uk/2012/01/06/frozen-embryo-ivf-babies-healthier_n_1186664.html" target="_hplink"><strong>Read the full story here</strong></a>.

  • Three Parent IVF

    Babies with three biological parents could soon be a reality after a new £6m laboratory has been given the go ahead and funding to develop a unique IVF technique which uses DNA from a third party. <a href="http://www.huffingtonpost.co.uk/2012/01/20/three-parent-ivf-may-be-legal_n_1218681.html" target="_hplink"><strong>Read the full story here</strong></a>.

  • Twins Beat The Odds To Be Born Five Years Apart

    Reception class pupil Reuben Blake went back to school today, but his twin sister will have to wait another five years until she is old enough. That is because, despite the fact the brother and sister were conceived from the same batch of embryos, they were born five years apart to parents Simon and Jody Blake. <a href="http://www.huffingtonpost.co.uk/2012/01/04/twins-born-five-years-apart-floren-simon-blake_n_1182717.html" target="_hplink"><strong>Read the full story here</strong></a>.

  • Lab-Grown Sperm - Coming Soon?

    Scientists have made a breakthrough that could enable infertile men to father children with their own sperm. Researchers at Muenster University in Germany grew mouse sperm in a laboratory and believe the same technique could be used with human sperm. <a href="http://www.huffingtonpost.co.uk/2012/01/03/sperm-grown-in-laboratory_n_1180695.html" target="_hplink"><strong>Read the full story here</strong></a>.

  • Scientists Uncover Female 'Fertility Switch'

    Scientists from the Imperial College London have discovered a 'fertility switch' that could help treat infertility and miscarriage in the future. <a href="http://www.huffingtonpost.co.uk/2011/10/17/new-hope-for-women-struggling-to-conceive_n_1015554.html" target="_hplink"><strong>Read the full story here</strong></a>.

  • Women Who Donate Eggs For IVF Will Have Payments Tripled

    The Human Fertilisation and Embryology Authority have announced today that women who donate their eggs to infertile couples, will be rewarded an extra £500 in costs. <a href="http://www.huffingtonpost.co.uk/2011/10/19/women-will-receive-triple-the-payment-for-egg-donation_n_1019830.html" target="_hplink"><strong>Read the full story here</strong></a>.

  • Baby Born Using 25-Year-Old Sperm

    A baby girl was born after being conceived using sperm that has been kept frozen for 25 years - the longest that sperm has been kept frozen and then successfully used for IVF in the UK. <a href="http://www.huffingtonpost.co.uk/2012/02/06/baby-conceived-by-oldest-frozen-sperm_n_1257653.html" target="_hplink"><strong>Read the full story here</strong></a>.

Plus fertility-boosting food you should be eating..

Loading Slideshow...
  • Natural Ways To Boost Your Fertility

  • Avoid White Bread, Pasta & Rice

    Although there is no direct link between refined carbohydrates and infertility, the refining process strips grains of some of the most important fertility-boosting nutrients, such as antioxidants, B vitamins and iron.

  • Go Organic

    Modern methods of food production, involving intensive farming, rob the soil of vital nutrients, so where possible stick to organic produce. Processed foods are packed with additives and preservatives that can upset blood sugar levels and disrupt the body's hormonal balance.

  • Cut Down On Red Meat

    Too much red meat increases the amount of ammonia in the body, which can interfere with the implantation of the egg in the uterus. Red meat can also be detrimental for men as it increases acidity and affects sperm activity; sperm perform better in alkaline conditions.

  • Switch To Soya Milk

    The animal hormones in dairy products can affect your own hormonal balance. If you balk at the richness of soya milk and can't bear to give up your semi-skimmed, switch to organic dairy products instead as these contain lower levels of hormones.

  • Reduce Your Alcohol Intake

    Giving up alcohol is not strictly necessary until you fall pregnant but it might be worth bearing in mind that Danish research, studying the link between alcohol consumption and fertility, found that <a href="http://www.ncbi.nlm.nih.gov/pubmed/12848646" target="_hplink">alcohol intake had a significant effect on infertility success</a> among women above the age of 30 who drank seven or more drinks a week.

  • Curb Caffeine

    While you don't need to give up your morning coffee, caffeine does constrict the blood vessels, slowing blood flow to the uterus and potentially making it harder for an egg to grab hold. So, if you're having any trouble conceiving, or undergoing IVF treatment, you might want to go easy on the double espressos.

  • Get Your Five-A-Day

    Aside from being packed with vitamins and minerals, fruit and vegetables are packed with antioxidants that attack free-radicals (harmful molecules that can damage the ova, sperm and reproductive organs).

  • Fertility-Friendly Vitamins

    Zinc helps to maintain a healthy menstrual cycle as well as being vital during pregnancy to aid cell division in a developing foetus. Folic acid (Vitamin B6), together with zinc, is essential in the function of female sex hormones. Vitamin B12 is also very important as it maximises the absorption of folic acid. Taking a multi-vitamin tablet designed especially for conception is a good way to ensure you're getting enough of these valuable nutrients. Marmite is also a great source!


FOLLOW UK LIFESTYLE

Scientists studying mice have identified a gene which could boost human fertility. Experts say the discovery, announced in a journal today, could help people struggling to conceive naturally. A ...
Scientists studying mice have identified a gene which could boost human fertility. Experts say the discovery, announced in a journal today, could help people struggling to conceive naturally. A ...
 
 
  • Comments
  • 2
  • Pending Comments
  • 0
  • View FAQ
Post Comment Preview Comment
To reply to a Comment: Click "Reply" at the bottom of the comment; after being approved your comment will appear directly underneath the comment you replied to.
View All
Favorites
Recency  | 
Popularity
This user has chosen to opt out of the Badges program
08:04 PM on 05/01/2012
When will be ALL become MAN made?

Reminds me of a film called I Robot, scary. I imagine the last man on earth, REAL man on earth I mean, with any knowledge whatsoever will be either hunted down or filmed in action.

Sounds like the novels, Demon SEED or The Running Man and The Stand! it's scary. I know a young couple that cannot have children because she's barren - or at least she herself hasn't conceived. I know that she was scared at first after two miscarriages and then she conceived a baby then lost it after three months. But, although she did quietly cry, they didn't hold a funeral, or make a big fuss, they just got on with life. It doesn't mean she doesn't love to see children, and everyone says she would have made a great mum, and her husband does too, but to keep messing about with genetics surely can be disasterous.

Where the HELL will it all end? God help us!
01:57 PM on 05/01/2012
This is all we need - a race of super-fertile humans in a crowded world. How many children could a couple have in their lifetime when the gene is switched on? If not, you have to add costs of contraception to expensive gene manipulation therapy once they have achieved their desired family size, or use more expensive gene manipulation to make them infertile again.
Sounds as if there is a tidy profit in this one....