Some have denied it. Some have refused to comment.
But as the UK Drug Policy Commission (UKDPC) calls for a wholesale review of the government's approach to illicit substances, we thought it was time for a reminder of the politicians who admit dabbling with narcotics.
From Michael Bloomberg ("You bet I did. And I enjoyed it") to Oliver Letwin, click the slideshow below for a comprehensive run-down of politicians left and right.
Louise Mensch told the world she took Class A drugs, <a href="http://www.dailymail.co.uk/news/article-2169677/Question-Time-Louise-Mensch-admits-did-Class-A-drugs-shocks-Johnny-Rotten.html">adding they "messed" with her brain.</a>
The former Tory chancellor has said: "I have not smoked cannabis. But I did eat a tiny bit of cannabis cake and all I can say is I enjoyed the cake but that is all."
Asked if he smoked cannabis in an interview before becoming the mayor of New York, he replied "You bet I did. And I enjoyed it."
The US president has admitted to using cocaine and marijuana. In his autobiography he wrote he liked "pot" and "maybe a little blow when you could afford it".
The shadow business secretary has <a href="http://www.dailymail.co.uk/news/article-2167424/Labour-MP-Chuka-Umunna-I-smoked-marijuana-I-teenager.html">admitted smoking cannabis as a teenager. </a>
The mayor of London has tried cocaine and marijuana. "I tried it [cocaine] at university and I remember it vividly. It achieved no pharmacological, psychotropic or any other effect on me whatsoever," he <a href="http://www.guardian.co.uk/uk/2007/jul/20/drugsandalcohol.immigrationpolicy">said of the former.</a> Of cannabis, he said: "It was jolly nice. But apparently it is very different these days. Much stronger. I've become very illiberal about it. I don't want my kids to take drugs."
Clinton famously smoked but didn't inhale.
"It was hard to go through Cambridge in the 70s without doing it a few times," Maude said of cannabis.
"I had two puffs and didn't like it," he said
Harriet Harman has admitted to doing cannabis, <a href="http://news.bbc.co.uk/2/hi/uk_news/politics/6907040.stm">telling the BBC: </a>"Yes I did when I was at university 30 years ago, just for a short time."
The former Home Secretary admitted to smoking cannabis. "I did break the law... I was wrong... drugs are wrong," she said.
"At Cambridge, I was a very pretentious student. I grew a beard and took up a pipe. On one occasion some friends put some dope in a pipe I was smoking. It had absolutely no effect on me at all. I don't inhale pipes," he has said.
Yvette Cooper was the first serving minister to <a href="http://news.bbc.co.uk/2/hi/uk_news/politics/971632.stm">admit smoking cannabis in 2000. </a>
While in government the former health secretary said he <a href="http://www.dailymail.co.uk/news/article-469445/Now-TEN-cabinet-ministers-admit-We-smoked-cannabis.html">had used it "once or twice."</a>
Former Labour minister Ruth Kelly admitted taking cannabis
Alistair Darling, the former chancellor, said he had smoked weed "occasionally in my youth."