A massive car bomb has exploded next to a police station in a central Damascus, killing at least ten people according to early reports.
The blast happened in the mainly Chrisitian Bab Touma district.
It comes as Syrian President Bashar al-Assad met with UN-Arab League peace envoy Lakhdar Brahimi who is calling for a temporary truce in the country's civil war.
The Syrian Observatory for Human Rights has said that a further 140 people were killed in violence Syria on Saturday.
More than 30,000 pople are thought to have died so far with 500,000 people made refugees since the start of the conflict last year.
A bomb in Lebanon on Saturday that killed intelligence officer Wissam al-Hassan has been linked to Syrian officials as fears grow that the civil war may be spreading in the region.