But following a remarkable turn of events - they have now become proud parents to four babies - two sets of twins!
While exploring all options to help them start a family, Misty and Brian started IVF treatment and asked a surrogate mum, family friend Amber Pluckebaum, to try and carry their baby, in the hope that one pregnancy would be successful.
Well, surprise! Misty and Amber both carried twins (three girls and one boy) to full term, and both sets were born in June 2012, just 35 hours apart!
Watch the video above to meet Misty, Brian and Amber, and new arrivals Connor, Hope, Madison and Victoria!