Smoking Is 'Important Risk Factor' For Schizophrenia, Scientists Claim

Posted: 26/03/2012 20:46 Updated: 26/03/2012 20:46   PA

Smoking Schizophrenia

Smoking should be considered an "important" risk factor for schizophrenia, a scientist has claimed.

Professor Boris Quednow, from the University Hospital of Psychiatry in Switzerland, led new research suggesting smoking increases the impact of schizophrenia genes.

Healthy smokers carrying the gene variants responded to an "acoustic stimuli" test in the same way as individuals suffering from the serious mental disorder.

The effect also appeared to be stronger the more a person smoked.

The study involved more than 1,800 participants who underwent a simple test which involves listening to a sequence of similar clicks.

Brainwave measurements show that most people suppress other, irrelevant, stimuli while processing the sounds.

However patients with schizophrenia appear to lack this filtering mechanism. As a result their brains are thought to be inundated with too much information.

Psychiatrically healthy people carrying variants of the gene TCF4 that increased the risk of schizophrenia also displayed poorer acoustic filtering, the study found. However, smoking appeared to amplify the effect, resulting in greater deficits.

The findings are published today in the journal Proceedings of the National Academy of Sciences.

Prof Quednow said: "Smoking alters the impact of the TCF4 gene on acoustic stimulus filtering. Therefore, smoking might also increase the impact of particular genes on the risk of schizophrenia.

"Smoking should... be considered as an important cofactor for the risk of schizophrenia in future studies."

People with schizophrenia frequently smoke, the researchers pointed out.

A combination of the click test and genetic and smoking data could be used to diagnose schizophrenia more rapidly and define new patient sub-groups, said Dr Quednow.

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  • Five Ways To Quit Smoking

    Battle the addiction with these top tips by hypnotherapist, <a href="www.elledormerhypnotherapy.co.uk" target="_hplink"><strong>Elle Dormer</strong></a>.

  • Close Your Eyes

    "Close your eyes and take 3 deep breaths in and out. Now build a mental picture of yourself in the future as a non smoker. "Make it real by filling in the detail - where you are, what you're doing, who you're with and how much better you look and feel. This is known as future pacing. If you can imagine yourself having achieved your goal you a mentally a step closer to it."

  • Plan Your Escape

    "Smokers often use cigarettes as a form of escapism. To have a break away from their desk after a stressful call. Or to provide thinking time when they are procrastinating. "Go for a brisk walk instead. Or to the kitchen to make a cup of tea. Any simple, familiar task that we can do without much thought allows us to simultaneously access our unconscious or 'zone out' which can be both relaxing and enable greater creative thought."

  • Imagine Other People's Disappointment

    "Make a list of all the people (alive or dead) in your life who care for you - or have cared for you, like your friends, partner, parents or children. Then close your eyes and imagine them all together gathered in a room. "You are standing before them with a large beautifully gift wrapped box. This present represents you quitting smoking. Explain this to them in your mind. See or imagine their reactions. "Make them real. The relief, love, pride, appreciation. Then imagine asking for the gift back and how sad and disappointed they would be. And resolve that you cannot do this to the people you love."

  • Breathe!

    "Cigarettes do not relax you. Nicotine is a stimulant so it is actually making you edgier and more stressed by elevating your heart rate and releasing stress hormones like adrenalin and cortisol into your blood stream. "Try an experiment: replace one of your regular cigarettes of the day with the following pattern of breathing. Breathe in for a count of 4 and out for a count of 8. Do this 10 x, consciously relaxing your body on every out breath. "This will physiologically de-stress you by slowing your heart rate and releasing endorphins. And prove to you you can truly relax yourself without a cigarette.

  • Use Your Imagination

    "Take a moment somewhere quiet and close your eyes. Remember a time when you felt really confident, relaxed and in control. Take yourself back to that time, fill in the details and make it real. When you're feeling those emotions at their strongest, squeeze our thumb and forefinger together. "Clear your mind and repeat. Then practice recalling those helpful, positive emotions at points during the day by squeezing your thumb and forefinger together. The physical trigger should help to access those beneficial feelings that will help at moments of weakness."

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Smoking should be considered an "important" risk factor for schizophrenia, a scientist has claimed. Professor Boris Quednow, from the University Hospital of Psychiatry in Switzerland, led new resea...
Smoking should be considered an "important" risk factor for schizophrenia, a scientist has claimed. Professor Boris Quednow, from the University Hospital of Psychiatry in Switzerland, led new resea...
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08:16 PM on 07/16/2012
"appeared to be stronger" "might also increase" "suggesting smoking increases" "smoking might also increase" These are all coded demands for more research money.
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Gayle Force Winds
Want some wine with that micro-bio?
02:24 PM on 07/11/2012
Smoking causes schizophrenia. I mean "doesn't" cause it. Well, maybe...not sure. Okay, it actually does cause it...very upset now...hand me a fag...
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HUFFPOST SUPER USER
Nathan0316
TrueBlueTory Age quod agis
01:29 PM on 03/27/2012
Having finally managed to quit smoking myself, I do find it annoying when I find the packs the little voices must have told me to buy...normally after a drunken night out on the tiles!
07:27 PM on 03/27/2012
Stop drinking. If reading that makes you feel argumentative, you may be drinking more to compensate.
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HUFFPOST SUPER USER
Nathan0316
TrueBlueTory Age quod agis
12:05 AM on 03/28/2012
Wow, that surgery to remove your sense of humour was completely successful wasn't it?
fredgladys
Your Micro-bio is empty, I know, stop nagging.
05:40 AM on 03/27/2012
I don't know about schizophrenia, but it certainly keeps you poor.
03:07 PM on 07/16/2012
Only because 83% of the pack price is tax that goes to Govt. The other paltry 17% is shared between tobacco companies and related business. Then Govt uses that money to attack legitimate adult consumers and fund made up studies like this one. Really Huff Post. Is this responsible reporting quoting "maybe" and "apparently" as scientific fact? If smoking does cause mental illness then it's because it causes Smokerphobia in some non smokers (similar to homophobia, xenophobia and Islamophobia) or an unfounded and hysterical fear of people who smoke. There should be some funding for research into that. The poor souls need treatment.
02:33 AM on 03/27/2012
What doesn't smoking cause?
03:40 AM on 03/27/2012
republicanism hopefully
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HUFFPOST SUPER USER
chatnuptime1
The Wolf's Den.
06:53 AM on 03/28/2012
Thats a birth defect. So I argue for more birth control.