Ageing Breakthrough: Scientists Discover 'Father Time' Gene

PA/The Huffington Post UK  |  Posted: 19/04/2012 22:01 Updated: 19/04/2012 22:01

Scientists has discovered four 'Father Time' genes that help determine how fast we age.

The ageing genes are switched on or off by environmental and lifestyle factors such as diet, and may be programmed from an early age.

Knowing how the genes are altered could pave the way to new generations of anti-ageing drugs, researchers believe.

Scientists already knew that "epigenetic" changes - chemical alterations to DNA made by external factors in the environment - are important to ageing.

The new research goes some way towards solving the riddle of how and when these effects occur.

Dr Jordana Bell, one of the study authors from King's College London, said: "We found that epigenetic changes associate with age-related traits that have previously been used to define biological age.

"We identified many age-related epigenetic changes, but four seemed to impact the rate of healthy ageing and potential longevity and we can use these findings as potential markers of ageing.

"These results can help understand the biological mechanisms underlying healthy ageing and age-related disease, and future work will explore how environmental effects can affect these epigenetic changes."

The scientists, whose work is reported in the online journal Public Library of Science Genetics, first looked for epigenetic changes in the DNA of 172 twins aged 32 to 80.

Twins are often used in such studies because identical pairs share exactly the same genes, making it possible to tease apart genetic and environmental effects. If one identical twin displays very different characteristics from the other it means the cause cannot be genetic.

Analysing the changes in relation to chronological age, the researchers identified 490 age-related epigenetic changes.

Matching these to specific age-related traits highlighted four genes displaying changes linked to cholesterol levels, lung function and maternal lifespan.

Further research showed that many of the epigenetic DNA alterations were also present in a group of 44 younger twins aged 22 to 61.

This suggests that while many age-related genetic changes caused by environmental factors occur throughout a person's life, some might be triggered early on.

Professor Tim Spector, director of the Department of Twin Research at King's College, said: "This study is the first glimpse of the potential that large twin studies have to find the key genes involved in ageing, how they can be modified by lifestyle and start to develop anti-ageing therapies.

"The future will be very exciting for age research."

Gene experts at the Wellcome Trust Sanger Institute in Hinxton, Cambridgeshire, played a key role in the study.

Sanger scientist Dr Panos Deloukas pointed out that the research was still at an early stage. "Our study interrogated only a fraction of sites in the genome (genetic code) that carry such epigenetic changes; these initial findings support the need for a more comprehensive scan of epigenetic variation," he said.

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Scientists has discovered four 'Father Time' genes that help determine how fast we age. The ageing genes are switched on or off by environmental and lifestyle factors such as diet, and may be progr...
Scientists has discovered four 'Father Time' genes that help determine how fast we age. The ageing genes are switched on or off by environmental and lifestyle factors such as diet, and may be progr...
 
 
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05:12 PM on 05/22/2012
I would totally give myself over to this study if they ever wanted to poke around at these "father time" genes. I would love to live forever! No matter how much heart ache might be endured by watching loved ones die. Its all in the name of Science, Plus it's probably a lot of peoples fantasies to live forever and stay young looking, I know I would LOVE that!
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Phytoresearcher
10:16 PM on 04/21/2012
There are legitimate anti-aging strategies and plant extracts that have been shown in peer reviewed clinical trials to either extend actual life span, as transmax resveratrol has, or prevent the diseases of aging such as diabetes, dementia, and cancer. These include resveratrol, pterostilbene, regular exercise, calorie restricted diets, intermittent fasting and telemere preserving compounds such as bio span.
This comment has been removed.
01:15 PM on 04/21/2012
Hopefully this will help sufferers of the horrible, terrible diesease Progeria.
Craigzz
God must like pinball
08:03 AM on 04/21/2012
Given that the planet earth has resources to support a maximum of 10 billion humans, and its now at 7, either women are going to have to stop churning out kids like smarties, or humans are going to have to die much younger, whatever, longevity will be the reserve of the very rich and powerful, as always. I'm a believer in the living earth, that as we continue to overpopulate and destroy it, the earth itself will exterminate us.
Kraptonfactor
They're coming to take me away ha ha, hee hee, ho
12:04 PM on 04/21/2012
craigzz, these women who are 'churning out kids like smarties' have been impregnated by a male. Just thought you needed reminding that babies are not the result of asexual reproduction.
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10:55 PM on 04/20/2012
In the words of Freddie Mercury/Queen... Who wants to live forever.
01:14 PM on 04/21/2012
No-one.. but this could help sufferers of that horrible diesease Progeria.
11:27 AM on 05/04/2012
i do, i dont ever want to die. death is the ultimate thief
08:29 PM on 04/20/2012
My daughter is only 36, dreadfully disabled and in constant pain which even morphine barely touches. Perish the thought that she would have to endure this for a further 70 years or so. Let nature take it's course and stop meddling with it for non priority causes.
06:25 PM on 05/06/2012
What illness does she have ?
12:14 PM on 04/20/2012
Following from earlier comments, meddling with the ageing process could only help the rich and powerful. The rest would have to continue working until ... well what 90?
Can you just imagine seeing the same tired faces for another 40 years - Elton John starring at the Queens centenary in 2052?
Simon Cowell still headlining celebrity news clips and/or running X Factor in 2050?
Shoot me now!
Where is everyone going to live? The cycle of life as we know it is parallel to the cycle of houses. Not only will younger people not find homes but (presumably) the longer we live the better able we will be to reproduce up to (say) 85 - and don't think that there won't be anyone who would actually want to.
Be careful what you wish for ...
10:36 PM on 04/20/2012
How can we reproduce, naturally, up the the age of 85?? The menopause is natures way of curtailing our ability to reproduce, and afterwards, usually around the age of 55 or so it is impossible to get pregnant, for the vast majority of people that is.
l don`t think epigenics will extend the time that women have their periods, and who would want to, certainly not me, and l am 65, and was glad to see the back of them!
Kraptonfactor
They're coming to take me away ha ha, hee hee, ho
12:11 PM on 04/21/2012
alameda11, men can impregnate women until they are very old. The quality of their sperm deteriorates with age but they are still capable of fathering children well into old age, they just need younger women who are still fertile.
06:59 PM on 04/21/2012
Firstly, it was all a bit tongue in cheek ...
... i've no idea how this works - there may be a dozen or so people in the world you do ... but if you could stop ageing then why shouldn't the uterus be part of it. There may be a question mark over the number of eggs available over an extended lifetime Our news is peppered with 50 something women who are desperate (see it as a right) to have children (usually at additional cost to the state).

The whole thing would be undesirable except for a handful of people with ageing illnesses and a whole lot of people with severe ego sickness believing that the world wants/needs them to live twice as long.
11:30 AM on 04/20/2012
Perhaps we will become a Society when you live to a certain age and then get terminated like in the Si-Fi film LOGAN'S RUN
11:05 AM on 04/20/2012
Population control will I fear come with this benefit of living longer of one kind or another.

States will impose penalties for obvious reasons as they do already on pensions, so it could be financial or it could be birth limitations, or wars, the extremity of which will depend on the size of the problem and how quickly they have to respond to it. These measures will also have to be universal as individuals and groups will always argue for exemption for one reason or another, just as some countries already are showing no signs of birth restraint so, without unilateral action from states, this leaves war as the only candidate.

Longevity of life suggests there wont be any health deterioration up until the end, but of course nature isn't like that so, how long will this be drawn out by, and will people consider this worth it considering the above?

I think nature has the upper hand ultimately and always will in this world of finite resources, and better nature should do this rather than human determination.
10:30 AM on 04/20/2012
It is a strange thought, especially if scientists somehow managed to create a drug that would maybe halt the ageing process, for example, you would get no older than the point at which you started taking the drugs. If an 18 year old wished to stay 18, then they could do that. Weird thought. Meddling in the extreme.
12:19 PM on 04/20/2012
Interesting problem SwissRon.
Most people over thirty really wouldn't want to have stayed 18 and many people over 50 would probably realise that the whole point of it all is to enjoy the progress of time and the joys (and set backs) of everyday living.
Whever you took 'the pill' you would regret it ...
Kraptonfactor
They're coming to take me away ha ha, hee hee, ho
12:19 PM on 04/21/2012
Wise post beechform. I'm not sure at what age I would have chosen to stay. My late 30's were my best years in some ways, health and fitness wise. I'm 55 now and have just taken early retirement in order to travel and do things I didn't have time for before. It would be nice to stay healthy in order to do so but staying young by artificial means creeps me out a bit, i would feel like a genetically modified being.
photo
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Susan Shaffer
watching you...
01:53 AM on 04/22/2012
as long as the mentality ages. Imagine the world over run with 18 year olds
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MsBubblyBlonde
Sassy,brassy,kiss my assy.
07:57 AM on 04/20/2012
The circle of life is such because as one person dies he makes room in the world for the one that's born.Surely by prolonging life they are causing huge problems for the world?Economically,more money to care for the people living past 70 etc ?More space to house everyone.Resources stretched to the limit.........and to be honest, who the hell would want to live any longer in a country that's gone down the pan?
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HUFFPOST SUPER USER
Phytoresearcher
06:21 AM on 04/20/2012
Epigenetic effects of a compound called transmax resveratrol, which is the particular form of the chemical found in red wine grapes, has been shown to up regulate the sirtuins, so-called longevity genes. Effects in animals range from a 31% (mouse and rat model) to a 59% (fish) increase in total lifespan. More importantly, transmax was shown to prevent the usual conditions, such as diabetes, heart disease and dementia, which accompany old age, thus increasing Health Span as well as life span. This compound is being studies in human clinical trials at a large number of university medical schools in the US and Europe.
Kraptonfactor
They're coming to take me away ha ha, hee hee, ho
12:28 PM on 04/21/2012
Phytoresearcher, I think 'good health span' is more important than longevity. If there was a pill that would keep me healthy (not necessarily for longer) I might consider taking it. Quality rather than quantity perhaps?
This comment has been removed.
05:00 AM on 04/20/2012
I wouldn't be surprised if the average lifespan for someone in their 20's now is over 100 years old.