Genetic 'Switch' Converts Damaged Heart Scar Tissue Into Muscle

PA/The Huffington Post UK  |  By Posted: 27/04/2012 09:08 Updated: 27/04/2012 09:08

Damaged hearts can be repaired using genetic "master switches" that convert scar tissue into muscle, research has shown.

The technique, demonstrated in mice, could lead to new treatments for heart attack survivors in the next decade, say scientists.

Scar tissue left by a heart attack can weaken the heart, making it incapable of pumping blood efficiently and leading to heart failure.

The debilitating condition, suffered by 900,000 people in the UK and 23m worldwide, causes exhaustion with even the slightest physical effort and may ultimately contribute to death.

Several groups of scientists are investigating the use of stem cells, immature cells with more than one development pathway, to rebuild scar-ridden hearts. But the new research points to a simpler method of turning scar tissue into functioning heart muscle without stem cell transplants.

Scientists in the US used microRNAs, small genetic molecules that serve as master regulators controlling the activity of multiple genes.

They identified a particular combination of three microRNAs that appeared to convert scar tissue cells called fibroblasts into heart muscle cells.

When the microRNAs were delivered into fibroblasts in the laboratory, the reprogrammed cells began to transform into the cardiomyocytes that make up heart muscle.

The same conversion was achieved in living mice, indicating that it had therapeutic potential.

Lead scientist Professor Victor Dzau, from Duke University Medical Centre in Durham, North Carolina, said: "Researchers have tried various approaches, including the use of stem cells, to regenerate damaged heart muscle tissue.

"This is the first study to use microRNA, which are small molecules that control gene expression, to reprogramme fibroblasts into heart muscle cells. We have not only shown evidence of this tissue regeneration in cell cultures, but also in mice."

He added: "This is a significant finding with many therapeutic implications.

"If you can do this in the heart, you can do it in the brain, the kidneys and other tissues. This is a whole new way of regenerating tissue."

The team, whose results are reported in the journal Circulation Research, now plans to see whether microRNAs can repair damaged hearts in larger animals. If these studies prove successful, human trials will follow.

Prof Dzau believes microRNA injections could prove a viable treatment for heart attack patients in years to come.

"If everything comes to fruition, I think we will see this as a therapy in the next decade," he said. "Conceivably, we'll use it to regenerate hearts damaged by heart attacks, avoiding heart failure and saving lives."

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  • Red Wine

    Red wine (when drank in moderation) can be good for the heart as it contains a powerful antioxidant called resveratrol, which helps prevent damage to blood vessels, reduces "bad" cholesterol and prevents blood clots.


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Damaged hearts can be repaired using genetic "master switches" that convert scar tissue into muscle, research has shown. The technique, demonstrated in mice, could lead to new treatments for heart ...
Damaged hearts can be repaired using genetic "master switches" that convert scar tissue into muscle, research has shown. The technique, demonstrated in mice, could lead to new treatments for heart ...
 
 
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19:02 on 27/04/2012
Good oh, 'gis us a new brain, doc!
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HUFFPOST SUPER USER
Fozwords
Abandon hope when you post on here
17:12 on 27/04/2012
Ther must be millions of super fit mice out there, or when they have completed their tests do they feed them to the snakes.
16:23 on 27/04/2012
aaaaarrrrrrhhhhh do you not realize that this world is in enough trouble without yet another way to prolong lives that nature dictates should be over.
Over population is a real problem, people are living unnaturally long lives due to medical intervention and it’s causing a massive imbalance, enough is enough, its wrong, so wrong.
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HUFFPOST SUPER USER
Fozwords
Abandon hope when you post on here
17:15 on 27/04/2012
Yeah anyone over fifty report to the crematorium, your on shifts. Get in line, fool.
18:56 on 27/04/2012
What a strange venomous reply, such anger in one so blinkered.
Perhaps in your case medical intervention would be a good idea before you spread the hate that you quite obviously cannot control.
Peace and Love
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normdoug
If we all loved, we could all live.
23:18 on 27/04/2012
Eh, I am well in line.
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HUFFPOST SUPER USER
Thomas Stieglitz
12:55 on 27/04/2012
Great day for mice--let's just hope this can be further refined and developed for humans.
22:03 on 27/04/2012
I wish they could find a cure for diabetes, both types. I have type 2, follow as good a diet as I can and go to the gym nearly every day and also have a personnal trainer but my doctor is still not happy
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HUFFPOST SUPER USER
Thomas Stieglitz
00:19 on 28/04/2012
Get a book called "Enter the Zone" by Barry Sears. Very good discussion about type 2 diabetes, gycemic index, and how to best manage the insulin resistance you have.
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susieq0408
It's all good, till it's not..
12:17 on 27/04/2012
As someone who just had a heart attack, that's very encouraging news!
17:36 on 27/04/2012
susieq0408: with 5 comments, at the moment, yours is the only sensible one.
18:56 on 27/04/2012
yours didnt really help much did it?