David Cameron's new Cabinet is set to meet for the first time after a reshuffle which was widely regarded as marking a shift to the right by the Conservative prime minister.
Cameron has replaced liberal Justice Secretary Kenneth Clarke with hardliner Chris Grayling, and appointed Jeremy Hunt as Health Secretary, with the job of selling the reforms introduced by Andrew Lansley, who has become Leader of the Commons.
Caroline Spelman was sacked as Environment Secretary in favour of Owen Paterson, a right-winger with a much more sceptical approach to subsidies for renewable energy.
Meanwhile, the Prime Minister was accused by London mayor Boris Johnson of plotting to ditch the Government's policy of refusing a third runway at Heathrow, after appointing Patrick McLoughlin Transport Secretary in place of Justine Greening, a vocal opponent of expansion at the airport, who moved to international development.
The changes were welcomed by some of Cameron's backbench Conservative critics on the right of the party, but are likely to dismay many Liberal Democrats.
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The five Lib Dem Cabinet ministers all retained their posts, but Business Secretary Vince Cable saw former Conservative co-chairman Michael Fallon installed as a "voice for business" in his department and Chancellor George Osborne's ex-chief of staff Matthew Hancock handed a junior ministerial role.
Further changes to junior posts in the Government were due to be announced on Wednesday, with Cameron expected to appoint members of the 2005 and 2010 intake of MPs as part of a bid to rejuvenate his administration with fresh faces from the back benches.
Among the backbenchers handed ministerial jobs were four women from the 2010 generation - Esther McVey, Helen Grant, Liz Truss and Anna Soubry. Cameron must be hoping that their appointment will help allay criticisms that he is falling behind on his own target of making one-third of his ministers female by the end of this Parliament.
Cameron's spokesman said the shake-up reflected a shift in focus as the Government moves into "the delivery phase" after two years of legislating for reform, adding: "This is a reshuffle that seeks to look to the future and bring in new people into the team and also ensure we have the right ministers in place to deliver the Government's programme."
But Labour dismissed the shake-up as a "no-change reshuffle" which had left the key ministers in charge of economic policy, including Osborne, in post. The new Cabinet will meet after PMQs at 10 Downing Street, where Cameron is expected to demand renewed vigour in the drive to restore growth.
Prime Minister David Cameron
Deputy Prime Minister Nick Clegg
Chancellor George Osborne
Foreign Secretary William Hague
Health Secretary Jeremy Hunt
After a stressful year in the DCMS, Jeremy Hunt moves from Culture to Health, replacing Andrew Lansley.
Home Secretary Theresa May
Cabinet Office Minister Francis Maude
Chief Secretary To The Treasury Danny Alexander
Minister without Portfolio, Ken Clarke
Having stepped down from the Justice Department, Clarke is supposedly staying in Government rather than hanging up his boots. Chris Grayling will replace him as Justice Secretary.
Justice Secretary Chris Grayling
Chris Grayling, formerly in the Department of Work and Pensions, will step up to hold the job vacated by Ken Clarke.
Culture Secretary Maria Miller
Maria Miller has taken up the DCMS job after Jeremy Hunt moved to the Department of Health. Miller is one of the few new faces in the cabinet.
Defence Secretary Philip Hammond
Communities Secretary Eric Pickles
Education Secretary Michael Gove
Minister for Internation Development, Justine Greening
Greening, who has been subject to plenty of rumours since her fallout over a potential third Heathrow runway. Greening was in No 10 for over an hour on Tuesday, presumably arguing her case and battling to stay in the cabinet. She will now take over Andrew Mitchell's spot at DfID.
Transport Secretary Patrick McLoughlin
McLoughlin, who has spent the past two years handling backbench rebels as Chief Whip, moves to the DfT, taking over from under-pressure Justine Greening. Greening has yet to be moved.
Energy Secretary Ed Davey
Attorney General Dominic Grieve
Cabinet Office Minister Oliver Letwin
Warsi, one of the earlest victims of the reshuffle, has been ousted as party co-chairman and is to be replaced by Grant Shapps. Warsi instead moves to to the Foreign Office as a junior minister, while also working as faith and communities minister.
Party Co-Chairman Grant Shapps
Shapps, who was the housing minister, is bumped up to party chairman, taking over from the demoted Sayeeda Warsi.
Environment Secretary Owen Paterson
Spelman leaves her post, to be replaced by the former Northern Ireland secretary Owen Paterson.
Work And Pensions Secretary Iain Duncan Smith
Leader of the House Andrew Lansley
Despite recently setting in motion huge overhauls to the NHS, Lansley has been moved to fill Sir George Young's spot as Leader of the House. Jeremy Hunt will succeed him in the Department of Health.
Business Secretary Vince Cable
Northern Ireland Secretary Theresa Villiers
Theresa Villiers, who gave nothing away as she approached Parliament with a wide smile on her face on Tuesday, replaces Owen Paterson. Paterson has moved to Defra.
Welsh Secretary David Jones
Cheryl Gillan was one name always likely to be taken off the list, and she is replaced by David Jones, who served beneath her as a Minister for Wales.
Scottish Secretary Michael Moore
Chief Whip Andrew Mitchell
Andrew Mitchell has moved moved from the Department for International Development to the role of Chief Whip, replacing Patrick McLoughlin.
Lords Leader Lord Strathclyde