Oprah - who is in the UK to promote her new film, 'The Butler - will appear on the ITV daytime show on Friday, sitting alongside regulars Andrea McLean, Lisa Maxwell, Nadia Sawalha and Sherrie Hewson.
The news was confirmed on the show's official Twitter page with an update which read: "Loose Women newsflash! Oprah Winfrey will be LIVE on UK TV this coming Friday at 12.30pm on Loose Women on @itv #OprahOnTheLoose."
'Loose Women' executive producer, Sharon Powers, added to The Sun: "She is the ultimate Loose Woman. It’s a fantastic coup for the show and we’ll be devoting virtually the entire programme to Oprah. We have so many questions to ask her."
Oprah's appearance follows a raft of changes for the show, including the exits of Denise Welch and Carol McGiffin, and the reintroduction of former panellists Coleen Nolan, Kaye Adams, Nadia Sawalha and Jane Moore.