Producers faced calls for the former boxer to be ejected from the house, after he claimed that being gay "ain't normal", adding that it was "a choice" which "could be fixed".
However, Ewin Holyfield has now said that his father would not "judge someone for their sexual orientation".
"My dad is the most loving and caring person you will ever meet. He treats everyone like a human being... even if they are homosexual," he told TMZ.
"My dad feels that being gay is a choice... and naturally that's how things work. You cannot procreate and make a baby with two women, or two men. But at the same time, my dad is not going to judge someone for their sexual orientation."
He added that Evander's former brother-in-law is gay and the star has always "treated him like a brother".
Evander's comments - which aired on the Channel 5 reality show on Sunday night - were met with widespread criticism on Twitter, with Boy George writing: "Shame, I had such admiration for Mr Evander Holyfield, he seemed dignified and I was sure he was a cool, smart, giant!"
Evander has since been reprimanded by Big Brother.