The first E20 resident to give evidence will be David Wicks, who recorded the murderer’s confession on Christmas Day 2013.
But will Janine, whose nasty ways and evil schemes have been delighting viewers since Charlie Brooks reprised her role in 2008, finally get her comeuppance?
Poor Alice Branning pleaded guilty for the crime after lawyers convinced her she'd get a lesser sentence.
However the plan didn't work too well and Alice, who has been jailed for good, won't be returning to our screens for the trial - leaving Janine free to give her own, unique spin on events.
Following her venomous confession, everyone knows Janine is guilty of murder, but this is Albert Square, where things rarely go to plan…
Watch 'EastEnders' on Thursday 13 March at 7.30pm to see the events unfold.