The 'This Morning' presenter was snapped wearing a lacy black dress, which she paired with red high heels, as she left Riverside Studios in London.
Holly announced earlier this year that she and her husband Dan Baldwin were expecting their third child, through a statement on her official website.
Glowing Holly Willoughby smiles for photographers
She is already a mother to four-year-old Harry and two-year-old Belle.
Holly has been a panelist on 'Celebrity Juice' since the show began in 2008 alongside Fearne Cotton, though Fearne took a break from the show while she was pregnant in 2013, during which time her spot was filled by Kelly Brook.
Keith Lemon, who hosts the show, has previously said he'd like Kelly to return to the show to do maternity cover for Holly, telling BANG Showbiz: "It makes sense for Kelly ‘cos she did a good job first time round."
Let's just hope Kelly isn't too busy - it was reported earlier this week that she had been offered a part in the comedy pilot 'One Big Happy' over in America.